Repressing the conserved pro-differentiation let-7 microRNAs through limiting Ago2 levels is critical to maintaining pluripotency in stem cells.

The cooperative antiviral activity of two distinct AGO proteins could be exploited to provide a new strategy for controlling viral diseases in rice.

Epithelial tumors secrete the ER-resident AGR2 in the extracellular matrix to function as a novel essential microenvironmental regulator of epithelial tissue architecture, which leads to tumorigenicity.

Genetic and biochemical analyses reveal that two stem-cell-specific microRNAs control stem cell fate decisions between pluripotency and differentiation through repressing Ago2, a key component of the microRNA machinery.

The central RNA interference protein, human Argonaute-2, releases its target following phosphorylation on a critical loop in the protein, freeing microRNA-bound Argonaute-2 to seek out and repress additional targets.

AGO protein-interacting exoribonucleases clear RNA induced silencing complex (RISC)-resulting 5' cleavage products in time to recycle RISC and miRNAs.

In transgenesis assays involving diploid model organisms, two clearly distinguishable transformation markers embedded in interweaved, but incompatible Lox site pairs allow the systematic creation of homozygous transgenic lines and minimize the number of wasted animals.

The Cajal body is essential for plants to deploy antiviral DNA methylation.

Small RNAs of distantly related plant pathogens, such as fungi and oomycetes, hijack the plant RNA-induced silencing complex to favor host infection.

A single microRNA-binding site in a long non-coding RNA alters T cell responses in vivo by 'sponging' the miRNA to inhibit its gene regulatory function.