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    1. Cell Biology

    Non-canonical function of an Hif-1α splice variant contributes to the sustained flight of locusts

    Ding Ding, Jie Zhang ... Le Kang
    The long-distance flight of locusts is greatly facilitated by a muscle-abundantly expressed Hif-1α splice variant, which remains active in normoxia and scavenges flight-induced reactive oxygen species by upregulating the expression of DJ-1 (PARK 7).
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Host-selected mutations converging on a global regulator drive an adaptive leap towards symbiosis in bacteria

    M Sabrina Pankey, Randi L Foxall ... Cheryl A Whistler
    Selective forces imposed by the squid animal host drive rapid adaptation of non-native Vibrio fischeri bacteria through convergent mutations of large effect, unmasking preexisting coordinated regulation of symbiosis.
    1. Cell Biology
    2. Plant Biology

    Orchestration of microtubules and the actin cytoskeleton in trichome cell shape determination by a plant-unique kinesin

    Juan Tian, Libo Han ... Zhaosheng Kong
    Kinesin-like calmodulin-binding protein integrates microtubules and F-actin to assemble the cytoskeletal configuration needed for trichome formation.
    1. Ecology

    Harbouring public good mutants within a pathogen population can increase both fitness and virulence

    Richard J Lindsay, Michael J Kershaw ... Ivana Gudelj
    Cooperation theory and a novel synthetic infection system provides a mechanistic understanding of why a seemingly successful disease management strategy can have devastating consequences for infected hosts.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status

    Dongming Li, Ana Marie S Palanca ... Julie A Law
    The METHYL-CpG-BINDING DOMAIN 7 (MBD7) complex promotes the activation (rather than repression) of transgenes that undergo DNA methylation and it does so without significantly altering their methylation status, placing this complex downstream of DNA methylation.
    1. Developmental Biology

    The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways

    Qingqing Zhu, Lu Song ... Naihe Jing
    The transcription factor Pou3f1 triggers embryonic stem cells to become neuronal progenitor cells in two ways: by activating the expression of pro-neuronal genes and by blocking external inhibitory signaling cascades.
    1. Developmental Biology

    Embryo-derive TNF promotes decidualization via fibroblast activation

    Si-Ting Chen, Wen-Wen Shi ... Zeng-Ming Yang
    Embryo-derived TNF promotes CPLA phosphorylation and arachidonic acid release from luminal epithelium to induce fibroblast activation and decidualization.
    1. Ecology
    2. Epidemiology and Global Health

    Landscape drives zoonotic malaria prevalence in non-human primates

    Emilia Johnson, Reuben Sunil Kumar Sharma ... Kimberly Fornace
    Regional meta-analysis enriches our understanding of zoonotic malaria in primate reservoirs in areas of Southeast Asia experiencing deforestation, with wider ecological implications for human disease risk in fragmented landscapes.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Insight into the evolution of microbial metabolism from the deep-branching bacterium, Thermovibrio ammonificans

    Donato Giovannelli, Stefan M Sievert ... Costantino Vetriani
    The genome of Thermovibrio ammonificans encodes ancestral pathways (e.g., hydrogen oxidation) and more recently acquired ones (e.g., nitrate reduction) and a hybrid pathway for CO2 fixation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit

    Inna Rozman Grinberg, Daniel Lundin ... Britt-Marie Sjöberg
    Structural and functional characterization of an unanticipated mode of allosteric activity regulation in ribonucleotide reductases controlled by an ATP-cone in the radical-generating subunit.