363 results found
    1. Plant Biology

    The AUX1-AFB1-CNGC14 module establishes a longitudinal root surface pH profile

    Nelson BC Serre, Daša Wernerová ... Matyáš Fendrych
    Plant roots can rapidly change the acidity of their cell walls and the root-soil interface to efficiently navigate in the soil environment.
    1. Computational and Systems Biology
    2. Plant Biology

    Computational modeling and quantitative physiology reveal central parameters for brassinosteroid-regulated early cell physiological processes linked to elongation growth of the Arabidopsis root

    Ruth Großeholz, Friederike Wanke ... Klaus Harter
    The recurring application of computational modelling combined with wet lab experiments identify and predict central regulatory parameters and factors for early cell physiological reactions linked to differential brassinosteroid-modified elongation growth in the root tip of Arabidopsis thaliana.
    1. Cell Biology
    2. Plant Biology

    TIR1/AFB-Aux/IAA auxin perception mediates rapid cell wall acidification and growth of Arabidopsis hypocotyls

    Matyáš Fendrych, Jeffrey Leung, Jiří Friml
    The nuclear pathway for auxin perception is responsible for the rapid auxin-induced cell wall acidification and growth of aerial organs of plants.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    The structure of photosystem I from a high-light-tolerant cyanobacteria

    Zachary Dobson, Safa Ahad ... Yuval Mazor
    The necessity of studying extremophile organisms is exemplified by the structure of photosystem I from a high-light tolerant cyanobacteria, demonstrating the relationship between the structure and function in photosystem I.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Exploring structural dynamics of a membrane protein by combining bioorthogonal chemistry and cysteine mutagenesis

    Kanchan Gupta, Gilman ES Toombes, Kenton J Swartz
    A facile method is implemented to modify membrane proteins with biophysical reporters using cysteine-independent approaches in live cells.
    1. Cell Biology
    2. Immunology and Inflammation

    Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE

    Miaomiao Li, Chih Yean Ong ... Ding Xu
    Heparan sulfate-RAGE interaction is essential for normal function of RAGE in osteoclastogenesis and drug-induced liver damage, which can be targeted to curb RAGE activation as a new opportunity.
    1. Neuroscience

    Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity

    Isaac M Chiu, Lee B Barrett ... Clifford J Woolf
    Molecular analysis paints a detailed picture of the distinctiveness and complexities of peripheral somatosensory neurons.
    1. Biochemistry and Chemical Biology

    Controlling protein function by fine-tuning conformational flexibility

    Sonja Schmid, Thorsten Hugel
    Specific and non-specific conformational confinement, via point mutation or cochaperone interaction or macro-molecular crowding, stimulates protein function in Hsp90 by reducing non-productive conformational flexibility.
    1. Microbiology and Infectious Disease

    4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen

    Hannah Tabakh, Adelle P McFarland ... Joshua J Woodward
    The aldehyde 4-hydroxy-2-nonenal is a novel component of the host antimicrobial reactive oxygen burst, and the bacterium Listeria monocytogenes encodes genes specifically for its detoxification.

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