72 results found
    1. Cell Biology

    Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

    Masroor Ahmad Paddar, Fulong Wang ... Vojo Deretic
    Membrane atg8ylation but not canonical autophagy control retromer-dependent endosomal sorting of cargo, including glucose transporter GLUT1, of general import and of significance for control of tuberculosis.
    1. Computational and Systems Biology

    MGPfactXMBD: A Model-Based Factorization Method for scRNA Data Unveils Bifurcating Transcriptional Modules Underlying Cell Fate Determination

    Jun Ren, Ying Zhou ... Qiyuan Li
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    NeuroSCAN: Exploring Neurodevelopment via Spatiotemporal Collation of Anatomical Networks

    Noelle L Koonce, Sarah E Emerson ... Daniel Colón-Ramos
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Protonation/deprotonation-driven switch for the redox stability of low-potential [4Fe-4S] ferredoxin

    Kei Wada, Kenji Kobayashi ... Masaki Unno
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Microbiology and Infectious Disease

    Evolutionary unique N-glycan-dependent protein quality control system plays pivotal roles in cellular fitness and extracellular vesicle transport in Cryptococcus neoformans

    Catia Mota, Kiseung Kim ... Hyun Ah Kang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Evolutionary Biology

    Still waters run deep: Large scale genome rearrangements in the evolution of morphologically conservative Polyplacophora

    Julia D Sigwart, Yunlong Li ... Jin Sun
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Computational and Systems Biology

    Discovering Root Causal Genes with High Throughput Perturbations

    Eric V Strobl, Eric Gamazon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy

    Yutaro Hama, Yuko Fujioka ... Nobuo N Noda
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cancer Biology

    Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer

    Phaedra C Ghazi, Kayla T O'Toole ... Martin McMahon
    Inhibiting KRASG12C and ULK-mediated autophagy is a novel treatment strategy to control the growth of KRASG12C-driven lung cancer in preclinical models of lung cancer.
    1. Neuroscience

    Anti-drift pose tracker (ADPT): A transformer-based network for robust animal pose estimation cross-species

    Guoling Tang, Yaning Han ... Pengfei Wei
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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