1,968 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Tuning apicobasal polarity and junctional recycling in the hemogenic endothelium orchestrates the morphodynamic complexity of emerging pre-hematopoietic stem cells

    Léa Torcq, Sara Majello ... Anne A Schmidt
    Pre-hematopoietic stem cells emerge from the aortic floor according to two radically different morphodynamics whose biomechanics rely on controlling apicobasal polarity in hemogenic precursors, which may impact on their fate.
    1. Neuroscience

    Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain

    Julio D Perez, Nimrod D Rubinstein ... Catherine Dulac
    A subset of genes in the mouse brain show dynamically regulated and unequal expression of maternally and paternally derived variants, with implications for brain development and function.
    1. Neuroscience

    Postural control of arm and fingers through integration of movement commands

    Scott T Albert, Alkis M Hadjiosif ... Reza Shadmehr
    After a movement, the final posture of the arm is stabilized by a subcortical structure that mathematically integrates movement commands over time.
    1. Evolutionary Biology

    Gene family innovation, conservation and loss on the animal stem lineage

    Daniel J Richter, Parinaz Fozouni ... Nicole King
    The genomes of animal progenitors evolved as mosaics of old, new, rearranged, and repurposed protein domains, genes and pathways and paved the way for the origin and evolution of animals.
    1. Neuroscience

    Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling

    Naomi AK Hanemaaijer, Marko A Popovic ... Maarten HP Kole
    High-speed calcium imaging from the axon initial segment shows that sodium channels are in part permeable to calcium ions.
    1. Neuroscience

    Statistical structure of locomotion and its modulation by odors

    Liangyu Tao, Siddhi Ozarkar ... Vikas Bhandawat
    A fly's locomotion can be decomposed into a small number of locomotor features which can be modulated by odors and other sensory information.
    1. Developmental Biology
    2. Plant Biology

    Formation of polarity convergences underlying shoot outgrowths

    Katie Abley, Susanna Sauret-Güeto ... Enrico Coen
    Models that generate tandem alignments of cell polarities are more readily compatible with the formation of PIN1 polarity patterns in plant leaf buds than the most widely accepted “up-the-gradient” model.
    1. Cell Biology
    2. Physics of Living Systems

    Cortical microtubule nucleation can organise the cytoskeleton of Drosophila oocytes to define the anteroposterior axis

    Philipp Khuc Trong, Hélène Doerflinger ... Raymond E Goldstein
    A three-dimensional description of the cytoskeletal arrangement, cytoplasmic flows, and cargo transport in stage 9 Drosophila oocytes accurately reproduces mRNA localizations in wild-type and mutant oocytes.
    1. Developmental Biology
    2. Neuroscience

    Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons

    Meike E van der Heijden, Elizabeth P Lackey ... Roy V Sillitoe
    Intersectional genetics show that excitatory neurons are essential for the functional and anatomical maturation of cerebellar circuits in mice.
    1. Ecology

    Little evidence that Eurasian jays protect their caches by responding to cues about a conspecific’s desire and visual perspective

    Piero Amodio, Benjamin G Farrar ... Nicola S Clayton
    Across five experiments, Eurasian jays’ caching behaviour provides little evidence of the ability to integrate cues about a potential pilferer’s visual perspective and desire and, challenging previous findings, to respond to either of the two social cues independently.

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