Quadri Adewale, Ahmed F Khan ... Alzheimer's Disease Neuroimaging Initiative
Identification of causal genes and their effects on other biological determinants untangles the complexities of aging and Alzheimer's and can facilitate drug discovery for sustaining healthy aging and treating Alzheimer's.
Felicia Reinitz, Elizabeth Y Chen ... Michael F Clarke
A neural precursor cell defect precedes widespread inflammation, amyloid plaque pathology, and cognitive deficit in Alzheimer's disease, which can be reversed by inhibiting USP16.
Mice modelling atherosclerosis show neurovascular breakdown in the cortex compared to healthy controls, and inducing atherosclerosis in mice modelling Alzheimer's disease increases the number of amyloid plaques in the hippocampus.
Joshua S Talboom, Asta Håberg ... Matthew J Huentelman
An internet-based cohort study of paired associate learning shows that a first-degree family history of dementia is associated with lowered performance, an effect modified by apolipoprotein E genotype and diabetes.
The early influence of the breakdown of both hippocampal structural network and angular gyrus-seeded default mode metabolism network on memory performance underscore the importance of early intervention in preclinical Alzheimer’s disease.
BADGERS, as a new powerful method for conducting polygenic score-based biobank-wide association scans, identified 48 significant associations for AD and 41 significant associations for a variety of AD endophenotypes.
Laura Sebastian Monasor, Stephan A Müller ... Sabina Tahirovic
APPPS1 microglia express disease-associated proteomic signatures of Alzheimer's disease earlier, compared to the APP-KI, and these differences correlate with the levels of fibrillar Aβ and impaired microglial phagocytic function.
Nuria Martin Flores, Marina Podpolny ... Patricia C Salinas
The Wnt antagonist DKK3 is a key regulator of excitatory and inhibitory synapses, and its downregulation in the hippocampus restores synaptic connectivity and memory in an Alzheimer's disease mouse model.
Mireia Seuma, Andre J Faure ... Benedetta Bolognesi
A massively parallel analysis of the effects of mutations on amyloid beta nucleation provide the first comprehensive atlas of how mutations alter the formation of amyloid fibrils.
