402 results found
    1. Neuroscience

    α-synuclein strains that cause distinct pathologies differentially inhibit proteasome

    Genjiro Suzuki et al.
    One α-synuclein strain inhibited proteasome activity and induced apparent pathologies, while the other did not, indicating a strain-dependent toxicity of α-synuclein aggregates, which support a prion-like behavior of α-synuclein.
    1. Neuroscience

    Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers

    Özgür Genç et al.
    Forward genetic screens define a novel genetic landscape by which diverse, unrelated autism risk genes may converge to commonly affect the robustness of synaptic transmission.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genetic and environmental determinants of variation in the plasma lipidome of older Australian twins

    Matthew WK Wong et al.
    A minor subset of plasma lipids are heritable, and this is associated with gene expression of transcripts related to roles beyond lipid metabolism, including immune function and cell signalling.
    1. Neuroscience

    Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability

    Yuliya Voskobiynyk et al.
    BIN1 forms a complex with Tau and voltage-gated calcium channels in neurons, and higher BIN1 levels promote neuronal activity, calcium influx, and bursting that is blocked by reducing Tau.
    1. Microbiology and Infectious Disease

    Apoptotic neurodegeneration in whitefly promotes the spread of TYLCV

    Shifan Wang et al.
    A plant virus, Tomato yellow leaf curl virus, manipulates the host preference of the vector insect whitefly to promote its transmission by inducing caspase-dependent apoptotic neurodegeneration in vector's brain.
    1. Cell Biology

    Miga-mediated endoplasmic reticulum–mitochondria contact sites regulate neuronal homeostasis

    Lingna Xu et al.
    Increasing endoplasmic reticulum (ER)–mitochondria contact sites leads to neurodegeneration.
    1. Neuroscience

    3,6’-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation

    Chih-Tung Lin et al.
    The new drug 3,6’-dithiopomalidomide mitigates key markers of neuronal death and neuroinflammation and improves acute behavioral outcome measures in traumatic brain injury, a common, debilitating disorder that lacks effective treatment.
    1. Neuroscience

    Three-dimensional synaptic organization of the human hippocampal CA1 field

    Marta Montero-Crespo et al.
    Volume electron microscopy reveals the synaptic organization of the neuropil of the human hippocampal CA1 field.
    1. Immunology and Inflammation
    2. Neuroscience

    Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain

    Jeremy Carlos Burns et al.
    Two novel subsets of microglia identified by their unique autofluorescence profiles differ in their subcellular organization, proteomic signatures and in their response to aging and lysosomal dysfunction.
    1. Neuroscience

    Sleep is bi-directionally modified by amyloid beta oligomers

    Güliz Gürel Özcan et al.
    Amyloid beta, the major component of plaques in Alzheimer's disease, acutely and reversibly signals to modulate sleep as a function of oligomeric length, independently of neuronal loss.

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