96 results found
    1. Developmental Biology

    Amotl2a interacts with the Hippo effector Yap1 and the Wnt/β-catenin effector Lef1 to control tissue size in zebrafish

    Sobhika Agarwala, Sandra Duquesne ... Virginie Lecaudey
    The cell junction-associated protein Amotl2a controls tissue size in the zebrafish lateral line primordium by limiting the activity of the Hippo effector Yap1 and the Wnt effector Lef1.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2

    Maya L Bulos, Edyta M Grzelak ... Michael J Bollong
    Screening repurposed drugs identifies that a clinical stage inhibitor splicing related kinases unexpectedly activates YAP driven transcription in cells.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Angiomotin functions in HIV-1 assembly and budding

    Gaelle Mercenne, Steven L Alam ... Wesley I Sundquist
    Angiomotin (AMOT) is a cellular host factor that links HIV-1 to the ubiquitin E3 ligase, NEDD4L, and promotes virion assembly and envelopment.
    1. Structural Biology and Molecular Biophysics

    Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity

    Zhijie Lin, Zhou Yang ... Mingjie Zhang
    A systematic and quantitative investigation showing how highly specific WW domain-mediated protein-protein interaction network is organized in cell growth and polarity.
    1. Cancer Biology
    2. Cell Biology

    Regulation of localization and function of the transcriptional co-activator YAP by angiomotin

    Susana Moleirinho, Sany Hoxha ... Joseph L Kissil
    Phosphorylation of Angiomotin regulates YAP localization and activity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites

    Amol K Bhandage, Gabriela C Olivera ... Antonio Barragan
    Intracellular parasites hijack a conserved GABAergic system of immune cells to promote dissemination.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress

    Jinyang Wang, Yaxin Wen ... Qinxi Li
    Acetate concentration, which is significantly increased in association with energy stresses such as those that occur with diabetes or starvation, is emerging as a novel 'ketone body' with potential as a parameter for evaluating the progression of energy stress.
    1. Neuroscience

    Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice

    Amol Bhandare, Joseph van de Wiel ... Nicholas Dale
    Recordings from brainstem nuclei involved in chemosensory regulation of breathing in awake freely behaving mice show different complementary types of neuronal responses to hypercapnia in the retrotrapezoid nucleus and the rostral medullary raphe.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria

    Alam García-Heredia, Amol Arunrao Pohane ... M Sloan Siegrist
    Peptidoglycan precursor synthesis occurs in both growing and non-growing regions of the mycobacterial cell surface.
    1. Developmental Biology

    Organ Size: Connecting physical cues and tissue patterning

    Damian Dalle Nogare, Ajay B Chitnis
    Version of Record
    Insight

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