Chronic excitation of the Caenorhabditis elegans oxygen-sensing neurons alters calcium homeostasis to accelerate the decline of neural plasticity with age.

Transcription factors form clusters independently of the presence of DNA, which regulate target genes as opposed to individual monomers, addressing a longstanding question of how transcription factors can find gene targets so quickly.

A combination of electrophysiological, immunocytochemical, and biochemical approaches elucidate the mechanisms by which the transcriptional regulator REST/NRSF rescues neuronal homeostasis by upregulating GABAergic transmission selectively onto excitatory neurons in response to hyperactivity.

While Trypanosoma congolense is mostly known to cause a chronic wasting disease in animals, a new mouse model shows that acute cerebral trypanosomiasis is triggered by parasite sequestration and infiltration of T helper cells in the brain parenchyma.

A human stem cell-derived in vitro model provided novel insights into the mechanisms of retinoid accumulation in, and permeation across, the blood–brain barrier.

Single-cell analysis of injured mouse sciatic nerves reveals rapid reprogramming of macrophages toward a glycolytic, proinflammatory phenotype during the early repair process.

Newly identified roles for the kinesin-1 light chain subunit KLC4 in patterning developing axon arbors, regulating microtubule dynamics and influencing behavior of larval and adult zebrafish.

Nanoscaleimaging reveals that animal septins form dense filamentous networks on biomimeticlipid membranes, explaining how septins may regulate cell surface rigidity.