Jeremy S Treger, Michael F Priest, Francisco Bezanilla
ArcLight, a popular optogenetic reporter of voltage, is studied at both single-molecule and macroscopic levels, which leads to new mechanistic understanding and to the rational design of a faster reporter.
Simon Chamberland, Helen H Yang ... François St-Pierre
The combination of a new genetically encoded voltage indicator and fast two-photon imaging methods enables detection of rapid neural electrical activity in organotypic slice cultures and in living flies.
Zachary A Knecht, Ana F Silbering ... Paul A Garrity
A combination of genetics, behavior and physiology demonstrate that cool and moisture sensing rely on overlapping combinations of sensory receptors in Drosophila.
Reto B Cola, Salome N Niethammer ... Tommaso Patriarchi
A new genetically encoded sensor robustly detects exogenously applied PAC1R ligands in vitro, ex vivo, and in vivo (in zebrafishes and mice) serving as a useful resource for probing PAC1R functions.
Stefanie Engert, Gabriella R Sterne ... Kristin Scott
Anatomical and synaptic reconstructions of gustatory axons from the adult Drosophila labellum reveal different classes of gustatory neurons recognizing different taste modalities.
Zachary A Knecht, Ana F Silbering ... Paul A Garrity
The neurons and receptors mediating moist air detection in Drosophila are identified, revealing that moist and dry air detection depend on overlapping Ionotropic Receptors and that these pathways are both critical for hygrosensation.
In Drosophila, key neurons controlling sleep play an important role in adjusting the temperature set-point before dawn via time-dependent neuronal plasticity within the clock circuits.