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    1. Neuroscience

    A Cryptochrome 2 mutation yields advanced sleep phase in humans

    Arisa Hirano et al.
    A missense mutation in the human Cryptochrome 2 (CRY2) gene leads to the condition of familial advanced sleep phase.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration

    Aida Rodrigo Albors et al.
    During axolotl spinal cord regeneration adult neural stem cells reactivate an embryonic neuroepithelial cell-like gene program that implements planar cell polarity to orient cell divisions, coupling polarized spinal cord growth with stem cell self-renewal.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Price equation captures the role of drug interactions and collateral effects in the evolution of multidrug resistance

    Erida Gjini, Kevin B Wood
    A simple mathematical model reveals that antibiotic interactions and collateral effects of evolution are inseparable drivers of multidrug resistance linked by the well-known Price equation from evolutionary theory.
    1. Ecology

    Habitat and social factors shape individual decisions and emergent group structure during baboon collective movement

    Ariana Strandburg-Peshkin et al.
    For baboons on the move, habitat features across multiple spatial scales combine with social interactions to impact the movements of individuals, ultimately shaping the structure of the whole group.
    1. Developmental Biology

    Dual control of pcdh8l/PCNS expression and function in Xenopus laevis neural crest cells by adam13/33 via the transcription factors tfap2α and arid3a

    Vikram Khedgikar et al.
    The regulation of tfap2α expression by adam13 is essential during cranial neural crest cell migration in Xenopus laevis.
    1. Structural Biology and Molecular Biophysics

    Structure and analysis of nanobody binding to the human ASIC1a ion channel

    Yangyu Wu et al.
    Development of specific and high-affinity nanobodies to probe the structure of human acid sensing ion channel-1a and as binding modifiers of the toxins PcTx and MitTx1.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls

    Fabian Rost et al.
    Building on previous work (Rodrigo Albors et al., 2015), we assess the contribution of individual cellular mechanisms in the context of spinal cord regeneration in the axolotl.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate

    Sabrina Vullo et al.
    Analysis of conformational changes indicates that activation of acid-sensing ion channels involves protonation of diverse extracellular sites and interaction of interdomain loops with the upper ends of transmembrane helices.
    1. Developmental Biology

    Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice

    Rita Carmona et al.
    Expression of the transcription factor Wt1 is required in a lateral mesoderm domain to develop the mesenchymal population required for the closure of the pleural cavities and the formation of the diaphragm.
    1. Developmental Biology
    2. Immunology and Inflammation

    Identification of polarized macrophage subsets in zebrafish

    Mai Nguyen-Chi et al.
    The discovery of evolutionarily conserved macrophage subsets in zebrafish paves the way for a comprehensive study of macrophage behaviour and function.