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    1. Evolutionary Biology
    2. Genetics and Genomics

    Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila

    Bhavatharini Kasinathan, Serafin U Colmenares III ... Harmit S Malik
    Heterochromatic sequences evolve rapidly, as do ZAD-ZNF genes-encoding proteins involved in heterochromatin functions, explaining why evolutionarily dynamic ZAD-ZNF genes are more likely to be essential in Drosophila.
    1. Chromosomes and Gene Expression

    The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells

    Dylane Detilleux, Peggy Raynaud ... Dominique Helmlinger
    A transcriptional coactivator turns into a repressor at specific genes in colorectal cancer cells.
    1. Stem Cells and Regenerative Medicine

    Derivation of trophoblast stem cells from naïve human pluripotent stem cells

    Chen Dong, Mariana Beltcheva ... Thorold W Theunissen
    Naive hPSCs can readily give rise to human trophoblast stem cells, thus demonstrating their extraembryonic lineage potential and providing a new model system to study human trophectoderm specification.
    1. Developmental Biology
    2. Neuroscience

    Radial glia regulate vascular patterning around the developing spinal cord

    Ryota L Matsuoka, Michele Marass ... Didier YR Stainier
    Identification of a novel role for central nervous system-resident progenitors in the patterning of the vascular network around the developing spinal cord.
    1. Neuroscience

    Persistent neural activity in auditory cortex is related to auditory working memory in humans and nonhuman primates

    Ying Huang, Artur Matysiak ... Michael Brosch
    The auditory cortex temporarily stores task-relevant information by persistently changed neuronal activity of single neurons and of neuronal populations.
    1. Evolutionary Biology

    Phylogenomics of white-eyes, a ‘great speciator’, reveals Indonesian archipelago as the center of lineage diversity

    Chyi Yin Gwee, Kritika M Garg ... Frank E Rheindt
    Contrary to the high absolute number of white-eyes in other parts of the world, the Indonesian archipelago is the center of phylogenetic diversity of this great speciator.
    1. Genetics and Genomics

    Data-driven, participatory characterization of farmer varieties discloses teff breeding potential under current and future climates

    Aemiro Bezabih Woldeyohannes, Sessen Daniel Iohannes ... Matteo Dell'Acqua
    A genomic, climatic, agronomic, and participatory characterization of teff agrobiodiversity shows opportunities and challenges of teff improvement in the face of climate change.
    1. Cell Biology

    CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels

    André Brás Gonçalves, Sarah Kirstine Hasselbalch ... Lotte Bang Pedersen
    Analysis of mutant cells combined with biochemical experiments reveals that CEP78 is recruited to the centrosome by CEP350 and regulates ciliogenesis and ciliary length control through CP110-dependent and CP110-independent mechanisms, respectively.
    1. Neuroscience

    Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum

    Javier Alegre-Cortés, María Sáez ... Ramon Reig
    Analysis of slow wave brain state unravels the functional connectivity and the biological substrate of the rodent dorsolateral and dorsomedial striatum, demonstrating its organization in two non-overlapping circuits.
    1. Computational and Systems Biology
    2. Neuroscience

    Decoding contextual influences on auditory perception from primary auditory cortex

    Bernhard Englitz, Sahar Akram ... Shihab Shamma
    The perception of ambiguous steps in relative tone height is predicted by direction-selective cells in the auditory cortex, rather than the brain's represented distance between the tone heights.