202 results found
    1. Cell Biology
    2. Immunology and Inflammation

    Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation

    Madison Bolger-Munro et al.
    Arp2/3 complex-mediated actin polymerization shapes how B lymphocytes probe the surface of antigen-presenting cells, promotes coalescence of B cell receptor (BCR) microclusters, amplifies BCR signaling, and enhances B cell activation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics

    Stanley Nithianantham et al.
    Soluble αβ-tubulin assembly is regulated by a cage-like molecular complex containing tubulin cofactors and Arl2.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP

    Luke A Helgeson, Brad J Nolen
    Single-molecule TIRF microscopy, biochemical assays and mathematical modeling demonstrate how actin-branch nucleation by the Arp2/3 complex is coordinately regulated by two biochemically distinct activators.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins

    Katja Gotthardt et al.
    The ciliary G-protein Arl13B – which is often mutated in Joubert syndrome – is the Guanine nucleotide exchange factor for the G-protein Arl3 and exclusively localizes to cilia.
    1. Cell Biology
    2. Immunology and Inflammation

    B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments

    Sophie I Roper et al.
    Two modes of actin polymerization, branched and linear, cooperate in B cells to extract antigens from surfaces of presenting cells.
    1. Cell Biology

    Switch-like Arp2/3 activation upon WASP and WIP recruitment to an apparent threshold level by multivalent linker proteins in vivo

    Yidi Sun et al.
    Intersectin counterparts in yeast recruit WASP and WIP to endocytic sites to establish a robust multivalent SH3 domain-PRM interaction network which gives actin assembly onset a switch-like behavior in vivo.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation

    Benjamin A Smith et al.
    New insights into the mechanism responsible for the nucleation of branches on networks of actin filaments shed light on a process that is essential for eukaryotic cell motility and endocytosis.
    1. Structural Biology and Molecular Biophysics

    Intraflagellar Transport: Moving proteins along in the cilium

    Narcis Adrian Petriman, Esben Lorentzen
    The structures of the bovine and human BBSome reveal that a conformational change is required to recruit the complex to the ciliary membrane.
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    1. Structural Biology and Molecular Biophysics

    Structure of the human BBSome core complex

    Björn Udo Klink et al.
    The structure of the human BBSome explains how the subunits interact with each other and how disease-causing mutations hamper this interaction.
    1. Structural Biology and Molecular Biophysics

    Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites

    Baoyu Chen et al.
    The cryo-electron microscopy structure of an assembly of the WAVE Regulatory Complex and its activator, the Rac GTPase, plus complementary biochemistry and biophysics, reveal a novel activation mechanism involving two distinct Rac binding sites.

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