10,009 results found
    1. Cell Biology
    2. Developmental Biology

    Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity

    Bart-Jan de Kreuk et al.
    The proteins Heart of Glass (HEG1) and Rasip1 are both essential for cardiovascular development; and directly bind to each other to guide Rasip1 to endothelial cell junctions to support vascular integrity.
  1. Point of View: Science, art, society and Klimt’s University of Vienna paintings

    Alberto E Pereda
    A set of paintings by Gustav Klimt highlights ongoing tensions in the relationships between art, science and society.
    1. Ecology
    2. Evolutionary Biology
    Rat illustration

    The Natural History of Model Organisms: The Norway rat, from an obnoxious pest to a laboratory pet

    Klaudia Modlinska, Wojciech Pisula
    The rat is much more than a simple model, and a better appreciation of the natural history of wild rats would increase its value as a research organism.
    1. Neuroscience

    Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure

    Aitak Farzi et al.
    CART exerts differential metabolic effects in response to activation of neurons of the Arc, where CART suppresses energy expenditure, while it enforces the reward characteristics of the LHA.
    1. Cell Biology

    Greatwall promotes cell transformation by hyperactivating AKT in human malignancies

    Jorge Vera et al.
    Greatwall is a new oncogene that induces AKT hyperphosphorylation by promoting the degradation of the phosphatase PHLPP.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres

    Rosa Maria Porreca et al.
    TRF1 suppresses replication fork stalling, which triggers break induced replication at telomeres associated with DNA damage response, alteration in the telomere chromatin environment, and re-localisation of telomeres to PML bodies.
    1. Neuroscience

    Motor cortex signals for each arm are mixed across hemispheres and neurons yet partitioned within the population response

    Katherine Cora Ames, Mark M Churchland
    Neurons in motor cortex contain information about each arm, but these signals are separated into different dimensions, allowing separate control of each arm.
    1. Neuroscience

    mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system

    Linqing Miao et al.
    The kinase AKT acts as a nodal point that coordinates both positive and negative cues to regulate the regeneration of central nervous system axons in adult mice.
    1. Cell Biology

    Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake

    Muheeb Beg et al.
    Distinct phosphorylations of Akt determine the regulation of glucose uptake into fat and epithelial cells, revealing unexpected specialization in both Akt activation and its downstream control of glucose metabolism.
    1. Ecology
    2. Evolutionary Biology

    Evolution of thorax architecture in ant castes highlights trade-off between flight and ground behaviors

    Roberto A Keller et al.
    Body shape and behavioural specializations found across the castes of ant species evolved together and reflect different abilities for ground behaviors.

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