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Mycobacterium tuberculosis (Mtb), effectors secreted through SecA2 pathway cause double strand breaks (DSBs) in the host DNA, which in turn activates ATM kinase to gain survival advantages, through Akt.

Global brain transduction of the instability-prone Mecp2 transgene by systemic AAV-PHP.eB administration is safe and effective in protecting male and female Mecp2 mutant mice from the Rett syndrome disease phenotype.

Genetic, pharmacologic, and optogenetic manipulations demonstrate that Purkinje cells can trigger and propagate the signals for tremor.

Two genetically distinct Stxbp1 haploinsufficiency mouse models exhibit seizures and impairments in cognitive, psychiatric, and motor functions, representing robust preclinical models of STXBP1 encephalopathy with both construct and face validity.

Two homologous kinesin motors, KIF5A and KIF5B, have distinct functions in dendritic spine morphogenesis, and KIF5B plays a role in synaptic plasticity and memory.

Signaling at the primary cilium is important to sustain the morphology, connectivity, and survival of a key neural population within the brain.

A combination of sensory-neuron specific conditional knockout mice reveal nodal beta spectrins are required to maintain, but not assemble, nodes of Ranvier.

An unbiased description reveals potential implications for understanding the developmental mechanisms that match respiratory supply and demand during hypoxia.

The Pk^pk and Pk^sple isoforms of the Prickle protein determine right- or left-handed bristle morphogenesis by coupling Frizzled/Vang signaling to the Fat/Dachsous PCP directional signal in opposite directions.

LAR-RPTPs are not essential for synapse formation, but they are important determinants of synapse properties as they contribute to regulate postsynaptic NMDA receptor function.