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Molecular pathway analysis towards understanding tissue vulnerability in spinocerebellar ataxia type 1
Terri M Driessen et al.
Unbiased transcriptomics reveals novel insights into the mechanisms that may contribute to regional neurodegeneration in SCA1, and other SCAs in general.
Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration
Kuchuan Chen et al.
the loss of Frataxin causes iron accumulation in the nervous system, which in turn enhances sphingolipid synthesis and activation of PDK1 and Mef2, which leads to neurodegeneration.
Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals
Kuchuan Chen et al.
The iron/sphingolipid/PDK1/Mef2 pathway is activated in mammals upon loss of Frataxin.
FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons
Haidun Yan et al.
The N-terminus of the FGF14b isoform promotes the inactivation of voltage-gated Na
channels to regulate the resurgent Na
channel current needed for high frequency action potentials.
Cerebellar patients have intact feedback control that can be leveraged to improve reaching
Amanda M Zimmet et al.
A control system model of cerebellar patients' movements provides insight into the cerebellum's role in reaching and informs a virtual reality intervention to improve patient reaches.
Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo
Jui-Yi Hsieh et al.
Electrophysiological analysis and imaging in live zebrafish reveal that infant- and adult-onset SCA13 mutations have distinct effects on the electrical activity, development, and survival of cerebellar Purkinje cells.
Learning: The cerebellum influences vocal timing
We are starting to understand how the cerebellum contributes to vocal learning in songbirds.
Biochemistry and Chemical Biology
Metal Biology: Bridging a gap in iron-sulfur cluster assembly
Erin L. McCarthy, Squire J. Booker
Brain Development: The impact of light during the night
Sophia TC Leung et al.
Exposing chicks to one hour of light during the night disrupts the releaseof a hormone that is needed by cells in the developing brain to survive.
Mitochondria: Selective protein degradation ensures cellular longevity
Sandra Malmgren Hill, Thomas Nyström
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