14 results found
    1. Genetics and Genomics
    2. Medicine

    EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence

    Jeremie Gautheron et al.
    Disruption of epoxide hydrolysis inducing oxidative stress and cellular senescence is a novel mechanism responsible for lipoatrophic monogenic diabetes.
    1. Cell Biology
    2. Immunology and Inflammation

    Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis

    Nadja Kern et al.
    Manipulating nanoscale spacing of Fcγ receptors using DNA origami demonstrates that ligand clustering regulates receptor phosphorylation and phagocytosis.
    1. Microbiology and Infectious Disease

    Bacterial symbiont subpopulations have different roles in a deep-sea symbiosis

    Tjorven Hinzke et al.
    Physiological differentiation during symbiosis leads to division of labor between smaller and larger cells in an uncultured bacterial tubeworm symbiont population and results in remarkable metabolic diversity and complexity.
    1. Computational and Systems Biology
    2. Ecology

    Combining agent-based, trait-based and demographic approaches to model coral-community dynamics

    Bruno Sylvain Carturan et al.
    A new agent-based model enables predicting how coral species richness and functional diversity affect the functioning and resilience of coral reef ecosystems.
    1. Neuroscience

    mPFC spindle cycles organize sparse thalamic activation and recently active CA1 cells during non-REM sleep

    Carmen Varela, Matthew A Wilson
    Sleep spindles provide a temporal framework to organize the reactivation of behaviorally relevant CA1 cells and sparsely active cells in the limbic thalamus.
    1. Ecology
    2. Evolutionary Biology

    Diverse deep-sea anglerfishes share a genetically reduced luminous symbiont that is acquired from the environment

    Lydia J Baker et al.
    Environmental transmission is atypical of symbionts that have undergone genome degradation, yet genetically reduced deep-sea anglerfish symbionts likely persist in the deep sea biome in search of a new host.
    1. Evolutionary Biology

    Computed tomography shows high fracture prevalence among physically active forager-horticulturalists with high fertility

    Jonathan Stieglitz et al.
    High reproductive effort constrains bone tissue response to physical activity-induced mechanical loading.
    1. Microbiology and Infectious Disease

    HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

    Pratibha C Koneru et al.
    Pyridine-based allosteric inhibitors selectively target HIV-1 integrase tetramers and exhibit enhanced antiviral activity against a dolutegravir resistant mutant virus indicating potential clinical benefits for combining these two classes of inhibitors.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    New insights into the cellular temporal response to proteostatic stress

    Justin Rendleman et al.
    A time-resolved analysis of protein and RNA concentrations and interactions during proteostasis stress highlights the dominant role of translation regulation and a shift of energy metabolism.
    1. Computational and Systems Biology
    2. Ecology

    Data-driven identification of potential Zika virus vectors

    Michelle V Evans et al.
    Data-driven methods predict over 35 mosquitoes are potential vectors of Zika virus, suggesting a larger geographic area and a greater human population is at risk of infection.

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