646 results found
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structural state recognition facilitates tip tracking of EB1 at growing microtubule ends

    Taylor A Reid et al.
    EB1 targeting to growing microtubule plus-ends is facilitated by tapered microtubule tip structures.
    1. Neuroscience

    The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats

    Paolo Campus et al.
    A top-down circuit generating from the prelimbic cortex and projecting to the paraventricular nucleus of the thalamus mediates individual differences in cue-elicited responding by affecting subcortical dopamine-dependent incentive learning.
    1. Neuroscience

    Humans can efficiently look for but not select multiple visual objects

    Eduard Ort et al.
    During search for multiple targets, individuals can efficiently prepare to select multiple target objects simultaneously, but the actual selection of those objects from the sensory input is limited.
    1. Neuroscience

    The nature of the animacy organization in human ventral temporal cortex

    Sushrut Thorat et al.
    The animacy organization in human ventral visual cortex is driven by both the presence of animal-diagnostic visual features and the psychological property of agency.
  1. PeerTax generated clusters

    PeerTax: Investigating the taxonomy of peer reviews

    We describe a machine learning approach towards understanding the fundamental components of peer-review reports.
    1. Structural Biology and Molecular Biophysics

    Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex

    Emiko Uchikawa et al.
    The identification of the insulin binding site 2 by high resolution cryo-EM analysis.
    1. Biochemistry and Chemical Biology

    Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a

    Gavin J Knott et al.
    An ancestral helical bundle governs whether the crRNA-processing nuclease of CRISPR-Cas12a is exploited by a phage-encoded allosteric anti-CRISPR.
    1. Neuroscience

    Chronically implanted Neuropixels probes enable high-yield recordings in freely moving mice

    Ashley L Juavinett et al.
    A new device enables researchers to use and recycle extracellular electrodes (e.g. Neuropixels) for high-yield recordings during freely moving mouse experiments.
    1. Immunology and Inflammation

    Multiplexed imaging of immune cells in staged multiple sclerosis lesions by mass cytometry

    Valeria Ramaglia et al.
    Imaging mass cytometry simultaneously lights up distinct immune cells in the brain.
    1. Neuroscience

    Metacontrol of decision-making strategies in human aging

    Florian Bolenz et al.
    Older adults show reduced adaptation of decision-making strategies to dynamically changing situational demands.

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