696 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions

    Luis V Nobre et al.
    The human cytomegalovirus (HCMV) interactome systematically characterises high-confidence viral-viral and viral-host protein interactions in HCMV-infected cells, facilitating multiple novel insights into HCMV and herpesviral function.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

    Ricardo Guerrero-Ferreira et al.
    Two new polymorphic structures of recombinant human alpha-synuclein fibrils show striking differences to previous structures, while familial PD mutation sites remain crucial for protofilament interaction and fibril stability.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Single cell transcriptional signatures of the human placenta in term and preterm parturition

    Roger Pique-Regi et al.
    Parturition gene regulation across multiple cell-types and placental compartments is deciphered at single cell resolution, highlighting the common role of the NFKB pathway in both term and preterm birth.
    1. Neuroscience

    MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment

    Flavio H Beraldo et al.
    Comprehensive dataset of high-level cognitive assessment in mouse models of neurodegeneration, accompanied by an open-access database/repository to change the paradigm of how cognitive studies in animal models can be shared/re-used.
    1. Genetics and Genomics

    Diversification of the Caenorhabditis heat shock response by Helitron transposable elements

    Jacob M Garrigues et al.
    Helitron transposable elements, by providing high density transcription factor binding sites upstream of host genes, have diversified the heat shock response within and among Caenorhabditis species.
    1. Developmental Biology

    VEGF/VEGFR2 signaling regulates hippocampal axon branching during development

    Robert Luck et al.
    Hippocampal axon branching, required for the formation of functional neuronal networks, is regulated by VEGF/VEGFR2 signaling during development.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

    Keisuke Kitakaze et al.
    Cell-based high-throughput screening identifies IBT21 as a chemical chaperone, that inhibits ER protein aggregation and prevents the cell death caused by a proteotoxin, the aggregation-prone prion protein.
    1. Neuroscience

    The computation of directional selectivity in the Drosophila OFF motion pathway

    Eyal Gruntman et al.
    ON and OFF visual motion is computed with the same algorithm despite differences in circuit architecture.
    1. Cell Biology
    2. Developmental Biology

    Myofibril diameter is set by a finely tuned mechanism of protein oligomerization in Drosophila

    Nicanor González-Morales et al.
    Myofibril diameter is set by the controlled oligomerization of the PDZ and LIM domain protein Zasp in Drosophila.
    1. Biochemistry and Chemical Biology

    Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation

    Eric R Greene et al.
    The 26S proteasome lid subcomplex acts as an external scaffold whose interactions with the ATPase motor stabilize the substrate-engagement-competent state, and control conformational changes upon engagement for subsequent degradation steps.

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