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    1. Computational and Systems Biology

    Point of View: Data science for the scientific life cycle

    Daphne Ezer, Kirstie Whitaker
    Each stage of the scientific life cycle stands to benefit from the introduction of data science techniques.
  1. Living Science: The importance of remembering

    Eve Marder
    Creativity in science requires the ability to recall information and data, and will suffer if we rely too much on technology to remember things for us.
    1. Human Biology and Medicine
    2. Neuroscience

    Point of View: Predictive regulation and human design

    Peter Sterling
    Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?
    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Cutting Edge: Building bridges between cellular and molecular structural biology

    Ardan Patwardhan et al.
    The integration of structural data from different imaging scales requires the development of standards and tools for representing the segmentation and transformation of data, and for the annotation of biological structures.
    1. Biochemistry and Chemical Biology

    Point of View: How open science helps researchers succeed

    Erin C McKiernan et al.
    Open research practices bring significant benefits to researchers.
  2. Philosophy of Biology: The challenges of big data biology

    Sabina Leonelli
    Understanding how data were collected and processed is an essential element of big data biology.
    1. Neuroscience

    Neurogliaform cortical interneurons derive from cells in the preoptic area

    Mathieu Niquille et al.
    In vivo genetic lineage-tracing reveals the developmental trajectory of neurogliaform cells, the main effectors of a powerful inhibitory motif in the neocortex.
    1. Neuroscience

    Altered topology of neural circuits in congenital prosopagnosia

    Gideon Rosenthal et al.
    An innovative inter-subject stimulus-locked brain activation approach uncovers marked topological differences in a brain network of higher-order visual regions in individuals with a congenital impairment in face recognition compared with controls.
    1. Microbiology and Infectious Disease

    An orphan cbb3-type cytochrome oxidase subunit supports Pseudomonas aeruginosa biofilm growth and virulence

    Jeanyoung Jo et al.
    During growth in biofilms and host infection, the opportunistic pathogen Pseudomonas aeruginosa employs respiratory heterocomplexes that support extracellular electron shuttling and pathogenicity.