Transgenic mice with high levels of FGF21 live for longer than wild-type mice and do so without reducing food intake.

A unique form of regulation has been observed in the unfolded protein response of S. pombe, along with a novel mechanism of post-transcriptional mRNA processing.

Electron microscopy has been used to produce the first three-dimensional image of the PRC2 gene-silencing complex.

Virtual reality experiments show that motorists slow down when driving in fog, but they speed up when visibility is reduced equally at all distances.

The transcription machinery used to regulate gene expression and self-renewal in human embryonic stem cells is different from that found in other cells.

A DNA–protein complex can find target sequences of bases in another DNA molecule by sliding along it.

A genome-organizing protein that is present only in the olfactory system of mice has been found to orchestrate changes in the relative numbers of different odor-sensing neurons on the basis of how active these neurons are.

A mathematical model based on enzyme kinetics shows how the relationships between life expectancy, survival rates for children and adults, and national income change over time.

A combination of advanced optical imaging and cryogenic electron microscopy has been used to explore membrane fusion in a synthetic system and provide new insights into neurotransmitter release.

Structural and functional studies of a potassium ion channel that is opened and closed by different ligands have revealed a novel gating mechanism.