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    1. Computational and Systems Biology
    2. Developmental Biology

    Motion sensing superpixels (MOSES) is a systematic computational framework to quantify and discover cellular motion phenotypes

    Felix Y Zhou, Carlos Ruiz-Puig ... Xin Lu
    A new computational framework provides a flexible and general approach for single and collective biological motion characterisation and phenotyping ideally suited for high-throughput timelapse screens.
    1. Developmental Biology
    2. Genetics and Genomics

    Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver-Russell syndrome-like mouse models

    Suhee Chang, Diana Fulmer ... Marisa S Bartolomei
    Precise dosage of the imprinted H19 and Igf2 genes is critical for normal embryonic development, especially related to the cardiac-placental axis.
    1. Neuroscience

    Differential inputs to striatal cholinergic and parvalbumin interneurons imply functional distinctions

    Jason R Klug, Max D Engelhardt ... Xin Jin
    A brain-wide mapping of the direct inputs to striatal cholinergic and parvalbumin interneurons reveals connectivity differences and implies their distinct roles in regulating striatal function.
    1. Evolutionary Biology
    2. Plant Biology

    An unexpected noncarpellate epigynous flower from the Jurassic of China

    Qiang Fu, Jose Bienvenido Diez ... Xin Wang
    Flowers did bloom in the Early Jurassic.
    1. Physics of Living Systems
    2. Cell Biology

    Mechanical heterogeneity along single cell-cell junctions is driven by lateral clustering of cadherins during vertebrate axis elongation

    Robert J Huebner, Abdul Naseer Malmi-Kakkada ... John B Wallingford
    Very local molecular patterns impart precise changes in the local mechanics of individual cell-cell junctions.
    1. Neuroscience

    Drosophila mechanical nociceptors preferentially sense localized poking

    Zhen Liu, Meng-Hua Wu ... Xin Liang
    A fly larval mechanical nociceptor develops dedicated neuronal mechanisms to support its sensory preference in detecting localized poking forces, and this sensory feature well supports the physiological function of the nociceptor in sensing the physical attack of its natural enemy.
    1. Medicine

    Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer

    Fernanda I Staquicini, Amin Hajitou ... Renata Pasqualini
    A peptide motif targeting tumor-infiltrating macrophage in triple-negative breast cancer delays tumor growth and favors an antitumor immune response.
    1. Developmental Biology
    2. Neuroscience

    A Notch-dependent transcriptional mechanism controls expression of temporal patterning factors in Drosophila medulla

    Alokananda Ray, Xin Li
    Cell-cycle-dependent Notch signaling cooperates with temporal transcription factors to promote the progression of the temporal transcription factor cascade in Drosophila medulla neuroblasts.
    1. Cell Biology

    α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism

    Amin Khalifeh-Soltani, Arnold Ha ... Kamran Atabai
    The milk protein Mfge8 promotes fat uptake and slows gastrointestinal motility to optimize nutrient absorption.
    1. Physics of Living Systems

    Mechanical basis and topological routes to cell elimination

    Siavash Monfared, Guruswami Ravichandran ... Amin Doostmohammadi
    Using self-organization, cells can collectively leverage defects in nematic and hexatic orders to localize mechanical stresses and remove an unwanted cell with their preferred path to achieve this explored here by independently tuning cell–cell and cell–substrate adhesion strengths.