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    1. Neuroscience

    Evolutionary shaping of human brain dynamics

    James C Pang, James K Rilling ... Luca Cocchi
    Human brains evolved to have neural dynamics that facilitate brain-wide integration supporting complex behavior.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in Caenorhabditis elegans

    Haikel Dridi, Frances Forrester ... Andrew Marks
    The Ryanodine receptor type 1 calcium channels play a critical role in age-related muscle function loss.
    1. Neuroscience

    Sensory cortex is optimized for prediction of future input

    Yosef Singer, Yayoi Teramoto ... Nicol S Harper
    Prediction of future input explains diverse neural tuning properties in sensory cortex.
    1. Computational and Systems Biology
    2. Ecology

    TRex, a fast multi-animal tracking system with markerless identification, and 2D estimation of posture and visual fields

    Tristan Walter, Iain D Couzin
    Being fast, memory efficient, easy to use, and with powerful integrated tools, TRex will lower barriers of entry into, and enable more ambitious approaches to, the quantitative study of behavior.
    1. Neuroscience

    Chronic pain induces generalized enhancement of aversion

    Qiaosheng Zhang, Toby Manders ... Jing Wang
    Chronic pain distorts intensity coding in the anterior cingulate cortex to give rise to generalized anatomically nonspecific enhancement in pain aversion.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Structural basis for the prion-like MAVS filaments in antiviral innate immunity

    Hui Xu, Xiaojing He ... Qiu-Xing Jiang
    Mitochondrial anti-viral signaling proteins form three-stranded helical filaments in launching innate immune responses against RNA viruses.
    1. Neuroscience

    Output variability across animals and levels in a motor system

    Angela Wenning, Brian J Norris ... Ronald L Calabrese
    Population output variability in a motor control system varies across levels (CPG, motor neurons, muscles) and can be ascribed to life history differences among animals and in some cases to differences between bilaterally homologous elements.
    1. Developmental Biology
    2. Neuroscience

    Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature

    Francesco A Servello, Rute Fernandes ... Javier Apfeld
    C. elegans nematodes can assess faithfully the threat that H2O2 poses by coupling the induction of their H2O2 defenses to the perception of high temperature—an inherent enhancer of the reactivity of H2O2.
    1. Neuroscience

    Body size as a metric for the affordable world

    Xinran Feng, Shan Xu ... Jia Liu
    The human body shapes how we perceive and interact with the environment, with body size serving as a boundary for defining potential actions, hereby enlightening research on foundation agents.
    1. Epidemiology and Global Health

    The role of adolescent lifestyle habits in biological aging: A prospective twin study

    Anna Kankaanpää, Asko Tolvanen ... Elina Sillanpää
    Unhealthy lifestyle habits in adolescence associate with accelerated biological aging in young adulthood, but shared genetic factors underlying both lifestyle and biological aging may largely explain the observed associations.