Single-cell RNA sequencing highlights the influence of host–pathogen interactions and stochasticity on transcriptional and phenotypic variance in lymphoblastoid cell lines derived from Epstein–Barr virus-infected primary B cells.
Caterina Carraro, Lorenzo Bonaguro ... Barbara Gatto
Combined analyses of transcriptome and chromatin accessibility elucidated the mechanisms underlying cancer cell lines response to antitumor candidates and provided a versatile perturbation-informed basal signature able to predict drug sensitivity.
Single-cell transcriptomes of olfactory receptor neurons at multiple developmental stages reveal cell-type-specific gene expression programs that underlie their development and sensory biology.
Edgar M Medina, Kristyn A Robinson ... Nicolas E Buchler
Spizellomycespunctatusis a genetically tractable chytrid and model organism for comparative cell biology for understanding evolution of the cell cycle, actin dynamics, and cellularization in fungi and early eukaryotes.
Elisa Monzón-Casanova, Louise S Matheson ... Martin Turner
The RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1) is essential for B cell development at the pro-B cell stage where it suppresses S-phase entry and promotes progression through mitosis.
Long-term physical exercise had a substantial effect on the plasma proteome, identifying novel exerkines and suggesting CD300LG as a potential link to insulin sensitivity.