7,739 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels

    Lilia Leisle et al.
    Combined simulations and electrophysiological experiments show that the CLC channels and exchangers form physically distinct and evolutionarily conserved pathways through which Cl- and H+ ions move when crossing biological membranes.
    1. Cell Biology

    Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans

    Yanan Sun et al.
    Cell biological and genetic studies reveal age-associated alterations of lysosomes and modulation of lysosomal activity by longevity pathways.
    1. Neuroscience

    Differences in reward biased spatial representations in the lateral septum and hippocampus

    Hannah S Wirtshafter, Matthew A Wilson
    Reward-related spatial information is preferentially represented in the lateral septum compared to the hippocampus and may be used downstream to direct the animal to rewarded locations.
    1. Structural Biology and Molecular Biophysics

    Structural insights into sodium transport by the oxaloacetate decarboxylase sodium pump

    Xin Xu et al.
    The structure of the membrane-integrated components of a unique substrate decarboxylation-driven primary-active sodium pump provides insights into its transport mechanism.
    1. Cell Biology
    2. Immunology and Inflammation

    Identification of a super-functional Tfh-like subpopulation in murine lupus by pattern perception

    Stefanie Gryzik et al.
    A novel binning approach provides evidence for super-functional T cells with high activation potential and which exhibit Tfh-like functionalities and can help B cells.
    1. Human Biology and Medicine
    2. Neuroscience

    A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

    June K Corrigan et al.
    The metabolic rate of mice is disproportionately affected by the site of experimentation, affecting the phenotypic interpretation of genetically modified strains.
    1. Neuroscience

    High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila

    Rui Huang et al.
    Fruit flies fed with high-fats diets are hyper-sensitive to a hunger hormone AKH and exhibit enhanced food-seeking behavior when starved.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanisms of nucleotide selection by telomerase

    Matthew A Schaich et al.
    The roles of key telomerase active site residues were elucidated to determine how telomerase selects the correct from the incorrect nucleotide to maintain telomere integrity.
  1. Racism in Science: We need to act now

    Michael B Eisen
    eLife, like the rest of science, must tackle the many inequalities experienced by Black scientists.
    Editorial
    Available as:
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    1. Computational and Systems Biology
    2. Developmental Biology

    An image-based data-driven analysis of cellular architecture in a developing tissue

    Jonas Hartmann et al.
    A computational strategy for extracting representative numerical features from 3D microscopy data enables in-depth quantitative analysis of cell and tissue organization through machine learning-driven data integration and context-guided visualization.

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