4,301 results found
    1. Immunology and Inflammation

    IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

    Mark Noviski et al.
    Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.
    1. Immunology and Inflammation

    B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk

    Kathrin Kläsener et al.
    Studying the earliest events in B cell activation reveals that the B cell antigen receptor is opened and activated via the phosphorylation and binding by the spleen tyrosine kinase (Syk).
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function

    Silvia Portugal et al.
    Atypical memory B cells (MBCs) appear to differentiate from classical MBCs during chronic exposure to the malaria parasite Plasmodium falciparum, and may interfere with the acquisition of immunity to the disease.
    1. Immunology and Inflammation

    Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity

    Marianne Burbage et al.
    Intersectin2 deficiency is associated with impaired humoral responses to viral infection and B-cell-intrisic defects in germinal centre formation, resulting from the reduced ability of intersectin2-KO B cells to establish cognate interactions with helper T cells.
    1. Cell Biology
    2. Immunology and Inflammation

    Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase

    Samina Shaheen et al.
    The combination of molecular imaging, genetic and pharmacological approaches revealed that BCR signaling and PKCβ-dependent activation of focal adhesion kinase (FAK) is required for B cell mechanosensing.
    1. Cell Biology
    2. Immunology and Inflammation

    Regulation of B cell fate by chronic activity of the IgE B cell receptor

    Zhiyong Yang et al.
    The immunoglobulin E (IgE) B cell receptor promotes plasma cell differentiation in the absence of cognate antigen and limits the competitive fitness of IgE+ B cells in germinal centers.
    1. Immunology and Inflammation

    Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory

    Bronwen R Burton et al.
    Investigation of antibody responses to variant Dengue virus proteins demonstrate new mechanisms that could increase the potential for vaccines to protect against mutable pathogens such as Flu, Dengue and HIV.
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection

    Alexander M Price et al.
    Epstein-Barr virus hijacks host anti-apoptotic machinery to ensure survival during latent infection.
    1. Immunology and Inflammation

    Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help

    Ting-ting Zhang et al.
    CD40 signaling is necessary to generate the immediate precursors of GC B cells, transition to the BCL6hi follicular state is promoted by a regional and transient diminution of T cell help.
    1. Cell Biology
    2. Immunology and Inflammation

    Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires

    Yang Yang et al.
    The B-1a cell heavy chain antibody repertoire differs dramatically from the follicular and marginal zone B cell repertoire and is defined by distinct mechanisms driven by self antigens rather than antigens derived from the microbiota.

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