5,430 results found
    1. Developmental Biology

    Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice

    Fabienne Benz et al.
    Endothelial tightening by augmenting low level Wnt/β-catenin activity in vessels of the mouse subfornical organ, influences neuronal activation in water-deprived mice, linking endothelial barrier properties to neuro-vascular coupling.
    1. Structural Biology and Molecular Biophysics

    Binding and transport of D-aspartate by the glutamate transporter homolog GltTk

    Valentina Arkhipova et al.
    Glutamate transporter homologs can efficiently bind and transport both L- and D- enantiomeric substrates with only slight rearrangements in the binding site.
    1. Neuroscience

    Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons

    Luis Carrillo-Reid et al.
    In mouse models of Huntington's disease, striatal spiny projection neurons up-regulate dendritic potassium channels, which impairs their normal function, but a zinc finger gene therapy can reverse this deficit.
    1. Biochemistry and Chemical Biology

    A bacterial riboswitch class for the thiamin precursor HMP-PP employs a terminator-embedded aptamer

    Ruben M Atilho et al.
    Many bacteria use a tiny riboswitch aptamer to sense the thiamin precursor HMP-PP to regulate the production of another thiamin precursor HET-P to efficiently biosynthesize this essential coenzyme.
    1. Cancer Biology
    2. Immunology and Inflammation

    CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

    Andrea Walens et al.
    CCL5-dependent macrophage recruitment drives breast cancer recurrence through collagen deposition in residual tumors.
    1. Genetics and Genomics

    Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

    Angela Schulz et al.
    Genetic and functional studies reveal a previously unrecognized role for a transmembrane protein in glomerular filtration barrier function.
    1. Epidemiology and Global Health

    Mapping imported malaria in Bangladesh using parasite genetic and human mobility data

    Hsiao-Han Chang et al.
    Human mobility drives malaria importation within countries and threatens elimination interventions, but can be measured using new approaches that combine parasite genetics, mobile phone data, travel surveys and models.
    1. Epidemiology and Global Health

    Using parasite genetic and human mobility data to infer local and cross-border malaria connectivity in Southern Africa

    Sofonias Tessema et al.
    Combining parasite genetic and human mobility data can provide detailed information on local and cross-border connectivity, allowing programs to strengthen local and regional coordination for successful elimination of malaria.
    1. Neuroscience

    Parallel visual circuitry in a basal chordate

    Matthew J Kourakis et al.

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