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    1. Neuroscience

    The neurons that mistook a hat for a face

    Michael J Arcaro, Carlos Ponce, Margaret Livingstone
    Neuronal recordings reveal complex, heterogeneous inputs to face-selective neurons, suggesting that inferotemporal neurons do not represent objects in isolation, but are also sensitive to object relationships that reflect environmental regularities.
    1. Epidemiology and Global Health

    Impact of COVID-19 pandemic on breast and cervical cancer screening in Denmark: A register-based study

    Mette Hartmann Nonboe, George Napolitano ... Elsebeth Lynge
    Denmark continued cancer screening during the pandemic, but following the first lockdown a temporary drop was seen in breast and cervical screening activity.
    1. Cancer Biology
    2. Cell Biology

    Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression

    Linda Julian, Gregory Naylor ... Michael F Olson
    In the absence of ROCK1 activation by caspases, apoptotic cells don’t undergo typical morphological changes, leading to sterile inflammation in the liver that increases tissue damage and suppresses tumor formation.
    1. Computational and Systems Biology
    2. Neuroscience

    Decoupling kinematics and mechanics reveals coding properties of trigeminal ganglion neurons in the rat vibrissal system

    Nicholas E Bush, Christopher L Schroeder ... Mitra JZ Hartmann
    Primary sensory neurons of the rat whisker system encode contact with objects in terms of the forces exerted on whiskers, rather than the induced whisker movements.
    1. Developmental Biology

    Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm

    Tessa G Montague, Alexander F Schier
    Nodal is assumed to be the sole inducer of mesendoderm, but the related signal Vg1 is as essential as Nodal in this process.
    1. Neuroscience

    Network structure of brain atrophy in de novo Parkinson's disease

    Yashar Zeighami, Miguel Ulla ... Alain Dagher
    The pattern of atrophy in Parkinson's disease is consistent with the disease spreading via intrinsic brain networks.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling

    C Keith Cassidy, Benjamin A Himes ... Peijun Zhang
    An atomic model of the bacterial chemosensory array obtained through the synthesis of cryo-electron tomography and large-scale molecular-dynamics simulations reveals a new kinase conformation during signaling events.
    1. Cell Biology
    2. Physics of Living Systems

    Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly

    Manuel Giménez-Andrés, Tadej Emeršič ... Alenka Čopič
    The amphipathic helix of perilipin 4 relies on the organization of its polar residues to form a remarkably immobile and stable protein layer on the surface of lipid droplets.
    1. Neuroscience

    Profound alteration in cutaneous primary afferent activity produced by inflammatory mediators

    Kristen M Smith-Edwards, Jennifer J DeBerry ... C Jeffery Woodbury
    Inflammatory pain, previously thought to result from increased activity in "pain" neurons, may in fact be due to wholesale changes in afferent output that includes increased and decreased activity that the brain interprets as pain.
    1. Cell Biology

    Uncoupling of dynamin polymerization and GTPase activity revealed by the conformation-specific nanobody dynab

    Valentina Galli, Rafael Sebastian ... Aurélien Roux
    Uncoupling of dynamin polymerization and GTPase activity can be induced with dynamin, which allows in vivo visualization of its activity at endocytic pits.