249 results found
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    The molecular architecture of engulfment during Bacillus subtilis sporulation

    Kanika Khanna et al.
    In situ cryo-electron tomography unveils the molecular sociology of a developing sporangium in Bacillus subtilis, revealing critical information about cell wall remodeling and membrane migration in bacteria.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    mRNA-programmed translation pauses in the targeting of E. coli membrane proteins

    Nir Fluman et al.
    Translation pauses occur in strategic positions to facilitate the production of properly folded membrane proteins in bacteria.
    1. Microbiology and infectious disease

    Asymmetric division triggers cell-specific gene expression through coupled capture and stabilization of a phosphatase

    Niels Bradshaw, Richard Losick
    Asymmetric cell division is linked to cell-specific transcription by handoff of a key developmental regulator from the cytokinetic machinery to the adjacent cell pole where it oligomerizes to become stabilized and activated.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Cell-wall remodeling drives engulfment during Bacillus subtilis sporulation

    Nikola Ojkic et al.
    Imaging experiments and simulations reveal that the biophysical mechanism for force generation needed to engulf a forespore is based on coordinated cell wall synthesis and degradation.
    1. Cell Biology

    Bacterial fumarase and L-malic acid are evolutionary ancient components of the DNA damage response

    Esti Singer et al.
    The dual function of an ancient prokaryotic enzyme, which is linked to specific metabolite signals, may have been the evolutionary driving force behind its dual localization in eukaryotes.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Visualization and functional dissection of coaxial paired SpoIIIE channels across the sporulation septum

    Jae Yen Shin et al.
    SpoIIIE forms a protein channel that spans the two lipid bilayers of the septum and mediates chromosome translocation and reversible membrane fission during Bacilus subtilis sporulation.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Mechanics and dynamics of translocating MreB filaments on curved membranes

    Felix Wong et al.
    Principal curvature-dependent motion of bacterial actin MreB results in localization consistent with all known literature.
    1. Microbiology and Infectious Disease

    MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis

    Saman Hussain et al.
    MreB filaments bind, orient, and move along the direction of greatest membrane curvature, thus orienting the insertion of new glycan strands around the cell circumference in a manner that may help establish and maintain rod shape.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Chromosome organization by one-sided and two-sided loop extrusion

    Edward J Banigan et al.
    Seemingly contradictory findings of single-molecule and in vivo experiments on a major mechanism of chromosome organization are reconciled by computationally investigating mechanisms of loop extrusion that are consistent with both.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

    Felipe Trajtenberg et al.
    The molecular mechanism of switching between phosphotransferase- and phosphatase-competent states in histidine-kinases has been uncovered, through direct crystallographic observation of bona fide complexes between a histidine-kinase and its response regulator from Bacillus subtilise.

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