418 results found
    1. Neuroscience

    Neuroscout, a unified platform for generalizable and reproducible fMRI research

    Alejandro de la Vega, Roberta Rocca ... Tal Yarkoni
    A web-based analysis platform for public fMRI data using naturalistic stimuli, leveraging state-of-the-art feature extraction models to enable more generalizable and reproducible findings.
    1. Genetics and Genomics

    The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay

    Karole N D'Orazio, Colin Chih-Chien Wu ... Rachel Green
    Cue2 is an endonuclease that cleaves mRNA in the A site of the lagging ribosome upon ribosome collision events.
    1. Neuroscience

    The large-scale organization of shape processing in the ventral and dorsal pathways

    Erez Freud, Jody C Culham ... Marlene Behrmann
    Functional neuroimaging reveals sensitivity to shape information and correlation between brain activation and perceptual behaviour in both dorsal and ventral visual pathways, thereby challenging the strict binary distinctions between the two pathways.
    1. Evolutionary Biology

    The Jurassic rise of squamates as supported by lepidosaur disparity and evolutionary rates

    Arnau Bolet, Thomas L Stubbs ... Michael J Benton
    Evidence for a largely unexplored radiation of squamates (lizards, snakes, and amphisbaenians) in the Middle to Late Jurassic is revealed by analyses of morphospace expansion, disparity, and evolutionary rates.
    1. Biochemistry and Chemical Biology

    Mechanisms of iron- and O2-sensing by the [4Fe-4S] cluster of the global iron regulator RirA

    Ma Teresa Pellicer Martinez, Jason C Crack ... Nick E Le Brun
    Molecular details of how the iron–sulfur cluster cofactor of a bacterial global iron regulatory protein simultaneously senses iron and O2 are revealed by mass spectrometry and spectroscopy.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity

    Gurmeet Kaur, A Maxwell Burroughs ... L Aravind
    Multicellular and socially aggregating prokaryotes contain previously undescribed, chaperone-based systems predicted to mediate defensive biological conflicts, several components of which are thematically similar antecedents of eukaryotic apoptosis pathways.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

    Peng Xie, Xu Jiang ... Chengqi Lin
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cell Biology
    2. Neuroscience

    The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease

    Aurelie de Rus Jacquet, Jenna L Tancredi ... Erin K O'Shea
    Extracellular vesicles are proposed as novel, non-cell-autonomous mediators of neuronal atrophy in Parkinson's disease.
    1. Microbiology and Infectious Disease

    Biofilms deform soft surfaces and disrupt epithelia

    Alice Cont, Tamara Rossy ... Alexandre Persat
    The growth of multicellular bacterial structures called biofilms generates forces that deform soft material substrates and disrupt epithelial cell layers, potentially mechanically damaging host tissue.
    1. Epidemiology and Global Health
    2. Medicine

    Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study

    Wuqing Huang, Jun Xiao ... Liangwan Chen
    A two-sample Mendelian randomization study suggested a potential causal relationship between HMGCR inhibition and the reduced risk of COVID-19 hospitalization.

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