Overexpression of BAG2—a novel mutant p53 binding protein—in tumors inhibits MDM2-mediated mutant p53 degradation, which leads to the accumulation of mutant p53 protein and promotes tumorigenesis.

Targeting the activation of the androgen receptor N-terminal domain by the cochaperone Bag-1L provides a new approach for inhibiting androgen receptor function to treat prostate cancer.

Non-core RAG regions, especially RAG1, maintain V(D)J recombination accuracy and genomic stability, reducing malignant characteristics and off-target recombination in BCR-ABL1⁺ B-cell acute lymphoblastic leukemia.

Inhibition of Notch signaling through the Jag2 ligand, blocks homeostatic sebocyte differentiation, and pushes the cells to a progenitor fate, in a reversible manner.

A deubiquitinase antagonizes the activity of an associated E3 ligase to prevent uncontrolled ubiquitination of a degradation machinery protein and thus maintain its functionality in protein quality control at the endoplasmic reticulum.

Simulations of a detailed network model show that the pattern of synaptic interactions resulting from learning is critical for the emergence of population bursts, sequential neuronal activity, and fast oscillations in the hippocampus.

The formation of mutually exclusive coding and non-coding transcription units contributes to transcriptional interference and insulation at gene clusters and manages state-switching in response to environmental change.

A novel mechanism links mechanical signals with the molecular YAP and NOTCH signals operating during developmental myogenesis.

A novel automated behavior analysis method for Hydra identifies pre-defined and new behavior types, and reveals a stable behavior repertoire.

The transcription factor GATA6 selects the embryonic vessels that will be reorganized into the major thoracic arteries by promoting local differentiation of vascular smooth muscle cells.