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    1. Cell Biology
    2. Immunology and Inflammation

    Apoptosis recognition receptors regulate skin tissue repair in mice

    Olivia Justynski, Kate Bridges ... Valerie Horsley
    After an injury to the skin, murine wounds upregulate apoptosis and efferocytosis pathways, which are required for effective healing and may similarly impact wound healing in diabetic patients.
    1. Developmental Biology
    2. Neuroscience

    Transcriptional control of motor pool formation and motor circuit connectivity by the LIM-HD protein Isl2

    Yunjeong Lee, In Seo Yeo ... Mi-Ryoung Song
    Isl2 orchestrates specific hindlimb motor pool arrangement, guaranteeing accurate motor control and sensorimotor circuit functionality.
    1. Cell Biology
    2. Neuroscience

    RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy

    Julie C Necarsulmer, Jeremy M Simon ... Todd J Cohen
    Impairing TDP-43 RNA-binding capacity through a single acetylation-mimic mutation alters TDP-43 function and recapitulates biochemical, molecular, and behavioral features of sporadic TDP-43 proteinopathies, thus providing opportunities for new research into pathogenic mechanisms and therapeutic interventions.
    1. Stem Cells and Regenerative Medicine

    Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

    Yaeko Nakajima-Takagi, Motohiko Oshima ... Atsushi Iwama
    Polycomb repressive complex 1.1 restricts precocious myeloid differentiation of hematopoietic stem/progenitor cells and expansion of myeloid progenitors, thereby serving as a gatekeeper of emergency myelopoiesis and myeloid transformation.
    1. Cell Biology

    A single-cell transcriptome atlas of pig skin characterizes anatomical positional heterogeneity

    Qin Zou, Rong Yuan ... Yanzhi Jiang
    The heterogeneity in molecule and function of three main cell types of smooth muscle cells, endothelial cells, and fibroblasts from both different anatomical sites of pig skin was comprehensively exposited.
    1. Genetics and Genomics

    Reassessment of weak parent-of-origin expression bias shows it rarely exists outside of known imprinted regions

    Carol A Edwards, William MD Watkinson ... Anne C Ferguson-Smith
    Genes with parent-of-origin specific expression are not as numerous as previously reported and validated parentally-biased expressed genes tend to be peripheral to known imprinted domains indicating shared regional control.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction

    Jacob M Winter, Heidi L Fresenius ... Jared Rutter
    A common genomic deletion in various human cancers disrupts mitochondrial protein homeostasis in a way that might be targeted by existing drugs.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Long non-coding RNA Neat1 and paraspeckle components are translational regulators in hypoxia

    Anne-Claire Godet, Emilie Roussel ... Anne-Catherine Prats
    LncRNA Neat1, with paraspeckle proteins, controls translational induction of (lymph)angiogenic and cardioprotective factors by the IRES-dependent mechanism in mouse cardiomyocytes submitted to hypoxia.
    1. Cell Biology

    Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations

    Linda K Krasniewski, Papiya Chakraborty ... Myriam Gorospe
    Single-cell analysis of skeletal mouse reveals highly diverse macrophage subgroups associated with diverse functions and age-related changes.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Alternative splicing of apoptosis genes promotes human T cell survival

    Davia Blake, Caleb M Radens ... Kristen W Lynch
    Alternative splicing of multiple apoptotic genes is enhanced by CD28 costimulation to promote cell survival.