2,621 results found
    1. Cell Biology
    2. Immunology and Inflammation

    Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation

    Madison Bolger-Munro et al.
    Arp2/3 complex-mediated actin polymerization shapes how B lymphocytes probe the surface of antigen-presenting cells, promotes coalescence of B cell receptor (BCR) microclusters, amplifies BCR signaling, and enhances B cell activation.
    1. Immunology and Inflammation

    The activation of IgM- or isotype-switched IgG- and IgE-BCR exhibits distinct mechanical force sensitivity and threshold

    Zhengpeng Wan et al.
    The B cell receptors of naïve B cells need higher levels of mechanical force to be fully activated than those of memory B cells.
    1. Immunology and Inflammation

    Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding

    Zhixun Shen et al.
    Conformational changes occur within extracellular domain of BCR upon antigen engagement, and these conformational changes are related with the strength of BCR activation and are distinct in IgM- and IgG-BCR.
    1. Developmental Biology
    2. Neuroscience

    The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest

    Joseph G Duman et al.
    The adhesion-GPCR BAI1 shapes dendritic arbors in the hippocampus by associating with Bcr late in development and stimulating its RhoA-GEF activity, resulting in dendritic growth arrest.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells

    Karmel A Allison et al.
    Pre-existing enhancers interpret T cell signaling strength in an analogue manner to direct quantitative changes in gene expression within the context of an overall digital response.
    1. Cell Biology
    2. Immunology and Inflammation

    Substrate stiffness governs the initiation of B cell activation by the concerted signaling of PKCβ and focal adhesion kinase

    Samina Shaheen et al.
    The combination of molecular imaging, genetic and pharmacological approaches revealed that BCR signaling and PKCβ-dependent activation of focal adhesion kinase (FAK) is required for B cell mechanosensing.
    1. Immunology and Inflammation

    Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

    Julia M Marchingo et al.
    Myc-dependent induction of amino acid transporter expression in response to T cell receptor activation is essential to enable T cell proteome remodelling upon immune activation.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Adequate immune response ensured by binary IL-2 and graded CD25 expression in a murine transfer model

    Franziska Fuhrmann et al.
    A murine adoptive transfer model shows that binary IL-2 and graded CD25 expression tailor the T helper cell response to the antigen amount in vivo.
    1. Immunology and Inflammation

    B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota

    Lieselotte SM Kreuk et al.
    Microbial-sensing TLRs drive responses to the microbiota, while nucleic-acid sensing TLRs control responses to endogenous ligands, revealing novel regulation of B-1a responses through integrated BCR/TLR mediated activation.
    1. Structural Biology and Molecular Biophysics

    How IGF-1 activates its receptor

    Jennifer M Kavran et al.
    Ligand binding to the ectodomain of the insulin-like growth factor receptor destabilises an autoinhibitory inter-subunit interaction, which allows the transmembrane domains to associate and the intracellular regions to autophosphorylate.

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