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Page 2 of 265
    1. Immunology and Inflammation

    The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets

    Takuya Koike et al.
    Unveiling a mechanism for the fate decision of B-cell differentiation into two functionally distinct memory B cell subsets.
    1. Cell Biology
    2. Immunology and Inflammation

    Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

    Sudha Kumari et al.
    T cell receptor signaling is regulated by newly polymerized F-actin foci at the immunological synapse.
    1. Immunology and Inflammation

    B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk

    Kathrin Kläsener et al.
    Studying the earliest events in B cell activation reveals that the B cell antigen receptor is opened and activated via the phosphorylation and binding by the spleen tyrosine kinase (Syk).
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The carboxyl-terminal sequence of bim enables bax activation and killing of unprimed cells

    Xiaoke Chi et al.
    The C-terminal membrane binding domain of Bim is shown to interact with and activate Bim enabling it to kill cells not dependent on anti-apoptotic proteins for survival.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling

    Claire Y Ma et al.
    The strength of TCR signalling determines the rate at which cells initiate a tightly coordinated signalling programme, without altering its organization.
    1. Immunology and Inflammation

    TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections

    Hannah P Savage et al.
    B-1 cell unresponsiveness to antigen-stimulation is overcome during infections when Toll-like receptor engagement removes negative regulators of B cell receptor signaling, thereby supporting B-1 cell differentiation to IgM-secreting plasmablasts.
    1. Immunology and Inflammation

    Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes

    Matthew B Stone et al.
    Clustering the B cell receptor generates a membrane domain analogous to the liquid-ordered phase, localizing proteins involved in early receptor activation.
    1. Plant Biology

    The transcriptional regulator BZR1 mediates trade-off between plant innate immunity and growth

    Rosa Lozano-Durán et al.
    The transcriptional regulator BZR1 acts as a molecular integrator of environmental cues regulating the trade-off between growth and innate immunity.
    1. Computational and Systems Biology
    2. Developmental Biology

    The dynamic transmission of positional information in stau- mutants during Drosophila embryogenesis

    Zhe Yang et al.
    In stau-mutants, the Hunchback boundary shifts posteriorly by 10% EL but shows comparable variability to that of the wild type in short time windows in nuclear cycle 14.
    1. Immunology and Inflammation

    Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor

    O Sascha Yousefi et al.
    Controlling the duration of ligand binding to the T cell receptor by light shows that T cells discriminate stimulatory from non-stimulatory ligands by measuring the dynamics of ligand binding.