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    1. Cell Biology

    The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions

    Hugo Siegfried, Georges Farkouh ... Mélina L Heuzé
    Depletion of VAPA in cancer cells induces defects in actin organization, adhesion dynamics and cell migration, together with a perturbation of phosphoinositide levels at the plasma membrane and a lack of anchoring of ER-PM contact sites to focal adhesions.
    1. Chromosomes and Gene Expression

    miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila

    Manish Pandey, Sakshi Bansal ... Geetanjali Chawla
    miR-125 functions as a potential dietary restriction mimetic by promoting longevity through regulation of fat metabolism.
    1. Neuroscience

    Slowly evolving dopaminergic activity modulates the moment-to-moment probability of reward-related self-timed movements

    Allison E Hamilos, Giulia Spedicato ... John A Assad
    Dynamic dopaminergic signaling modulates the timing of reward-related movements by tuning the moment-to-moment probability of their onset.
    1. Immunology and Inflammation
    2. Medicine

    Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis

    Ada Weinstock, Karishma Rahman ... Edward A Fisher
    Wnt signaling is revealed to be a regulator of macrophage inflammation-resolving state in atherosclerosis through a PGE2-mediated pathway.
    1. Computational and Systems Biology
    2. Neuroscience

    Mesoscale cortex-wide neural dynamics predict self-initiated actions in mice several seconds prior to movement

    Catalin Mitelut, Yongxu Zhang ... Timothy H Murphy
    Mouse self-initiated behaviors can be identified seconds prior to action and have similar neuro-dynamical structure to neural dynamics underlying human voluntary actions supporting the use of mouse models in self-initiated and volitional action research.
    1. Neuroscience

    Controllability boosts neural and cognitive signatures of changes-of-mind in uncertain environments

    Marion Rouault, Aurélien Weiss ... Valentin Wyart
    Task controllability manipulations reveal that information seeking is associated with reduced confidence and active hypothesis testing, as well as stronger neurophysiological correlates of attention and arousal.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations

    H Nayanga Thirimanne, Feinan Wu ... Bruce E Clurman
    Genome-wide analyses reveal how tumor-associated mutations of the Fbw7 ubiquitin ligase impact oncogenic transcription factors and gene expression.
    1. Medicine
    2. Immunology and Inflammation

    Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

    Hengqi Betty Zheng, Benjamin A. Doran ... Leslie S. Kean
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Valence biases in reinforcement learning shift across adolescence and modulate subsequent memory

    Gail M Rosenbaum, Hannah L Grassie, Catherine A Hartley
    Relative to children and adults, adolescents placed greater weight on negative prediction errors during learning and these age-varying learning idiosyncrasies biased subsequent memory for information associated with valenced outcomes.
    1. Neuroscience

    How relevant is the prior? Bayesian causal inference for dynamic perception in volatile environments

    David Meijer, Roberto Barumerli, Robert Baumgartner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid