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Page 3 of 156
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolutionary dynamics of transposable elements in bdelloid rotifers

    Reuben W Nowell, Christopher G Wilson ... Timothy G Barraclough
    An investigation of transposable element evolution in a group of long-term asexual animals shows that many of the predicted effects of asexuality are not observed.
  1. Nuclear pore assembly proceeds by an inside-out extrusion of the nuclear envelope

    Shotaro Otsuka, Khanh Huy Bui ... Jan Ellenberg
    Nuclear pores assemble asymmetrically, by an inside-out evagination of the inner nuclear membrane that grows in diameter and depth until it fuses with the flat outer nuclear membrane.
    1. Cell Biology
    2. Physics of Living Systems

    A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

    David Trombley McSwiggen, Helen Liu ... Hilary P Beck
    Single-molecule tracking at scale, analyzing millions of cells and thousands of compounds per day, demonstrates that measuring protein motion provides mechanistic insights relevant to drug discovery.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols

    Vayu Maini Rekdal, Paola Nol Bernadino ... Emily P Balskus
    A previously unrecognized group of metalloenzymes enables human gut microbes to metabolize dietary molecules and neurotransmitters and likely mediates interactions and metabolism among environmental microorganisms.
    1. Neuroscience

    Statistical structure of locomotion and its modulation by odors

    Liangyu Tao, Siddhi Ozarkar ... Vikas Bhandawat
    A fly's locomotion can be decomposed into a small number of locomotor features which can be modulated by odors and other sensory information.
    1. Neuroscience

    All-trans retinoic acid induces synaptic plasticity in human cortical neurons

    Maximilian Lenz, Pia Kruse ... Andreas Vlachos
    The vitamin A derivative, all-trans retinoic acid, induces protein-synthesis-dependent synaptic plasticity in the human brain.
    1. Cell Biology
    2. Medicine

    Sclerostin small-molecule inhibitors promote osteogenesis by activating canonical Wnt and BMP pathways

    Sreedhara Sangadala, Chi Heon Kim ... Steven M Presciutti
    Locally delivered small-molecule sclerostin inhibitors are able to promote local osteogenesis in vitro and in clinically relevant in vivo models by simultaneously activating the canonical Wnt and BMP signaling pathways.
    1. Neuroscience

    Distinct contributions of functional and deep neural network features to representational similarity of scenes in human brain and behavior

    Iris IA Groen, Michelle R Greene ... Chris I Baker
    Deep network features exhibit a robust correlation with brain activity in scene-selective cortex, but are not sufficient to explain human scene categorization behavior, which is strongly shaped by information about the function (possibility for action) of the scene.
    1. Developmental Biology
    2. Genetics and Genomics

    Smchd1 is a maternal effect gene required for genomic imprinting

    Iromi Wanigasuriya, Quentin Gouil ... Marnie E Blewitt
    Imprinted gene expression is set up during a critical window of early embryonic development, by the translation of parental imprints by oocyte-supplied Smchd1 into allele-specific gene silencing.
    1. Neuroscience

    Aberrant hippocampal Ca2+ microwaves following synapsin-dependent adeno-associated viral expression of Ca2+ indicators

    Nicola Masala, Manuel Mittag ... Tony Kelly
    Common adeno-associated viral transduction procedures induce artefactual spatially confined Ca2+ waves in the hippocampus.