177 results found
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish

    Mounir El Maï et al.
    Telomere shortening with age promotes a switch from p53-dependent apoptosis to senescence prompted by tissue damage that triggers conflicting mTOR/AKT signalling, lower OxPhos defences and ROS, mitochondria dysfunction and senescence.
    1. Neuroscience

    Wireless recording from unrestrained monkeys reveals motor goal encoding beyond immediate reach in frontoparietal cortex

    Michael Berger et al.
    The novel Reach Cage allows neurophysiology studies of structured behavior with unrestrained Rhesus macaques showing that the frontoparietal reach network is selective for reach goals outside the immediately reachable space.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    An advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases

    Julia Bittmann et al.
    The development of an advanced cell cycle tag toolbox will enable a wide variety of cell cycle studies and shows post-replicative function of nucleases resolving replication/recombination structures.
    1. Neuroscience

    Diminished responses to bodily threat and blunted interoception in suicide attempters

    Danielle C DeVille et al.
    People who have attempted suicide exhibit blunted sensory processing during breathing and pain perturbations, as well as lower heartbeat perception accuracy and reduced mid/posterior insula activity during interoceptive attention.
    1. Genetics and Genomics

    Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria

    Tracy L McGregor et al.
    Lifelong HAO1 knockout was safe and without clinical phenotype in an identified healthy woman, de-risking a rare disease therapeutic approach through the power of naturally occurring human genetic variation.
    1. Epidemiology and Global Health

    The hazards of smoking and the benefits of cessation: a critical summation of the epidemiological evidence in high-income countries

    Prabhat Jha
    Cumulatively, from 1950 to 2015, smoking-related disease has been the biggest cause of premature death in high-income countries, with elevated risks of smoking continuing well into the 21st century.
    1. Genetics and Genomics

    Variable prediction accuracy of polygenic scores within an ancestry group

    Hakhamanesh Mostafavi et al.
    The prediction accuracies of polygenic scores in humans vary depending on the characteristics of the samples, as well as based on the study design, within a single ancestry group.
    1. Human Biology and Medicine
    2. Immunology and Inflammation

    p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

    Hui Che et al.
    A novel IVDD mechanism that involves p16 is demonstrated and theoretical evidence is provided for effective methods to downregulate p16 and so reverse IVDD.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Adjusting for age improves identification of gut microbiome alterations in multiple diseases

    Tarini S Ghosh et al.
    A multi-cohort analysis of 2,500 gut microbiomes and five major diseases discovers that disease-microbiome associations display specific age-centric trends, with diseases characterized by age-centric trends of species gain/loss.
    1. Immunology and Inflammation

    Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

    Heledd H Jarosz-Griffiths et al.
    CFTR modulators have potent innate anti-inflammatory properties that can be measured in clinic, both ex vivo and in vitro, which can be used to predict treatment efficacy.

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