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    1. Neuroscience

    Endocannabinoid signaling enhances visual responses through modulation of intracellular chloride levels in retinal ganglion cells

    Loïs S Miraucourt et al.
    Endocannabinoid activation of the CB1 receptor on retinal ganglion cells in the eye results in enhanced excitability and responsiveness to visual stimulation through a novel mechanism involving intracellular chloride regulation.
    1. Cell Biology
    2. Developmental Biology

    An in vitro stem cell model of human epiblast and yolk sac interaction

    Kirsty ML Mackinlay et al.
    Human yolk sac-like cells, which share characteristics with the post-implantation human hypoblast, can model the interaction between the epiblast and hypoblast that occurs during early human development.
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection

    Alexander M Price et al.
    Epstein-Barr virus hijacks host anti-apoptotic machinery to ensure survival during latent infection.
    1. Biochemistry and Chemical Biology

    Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine

    Qiang Liu et al.
    Identifying and understanding that local anesthetic dyclonine targets TRPV3 channels will help to conceive therapeutic interventions.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    A new view of transcriptome complexity and regulation through the lens of local splicing variations

    Jorge Vaquero-Garcia et al.
    New methods reveal that complex local splicing variations are more prevalent in animals than previously appreciated, and demonstrate that local splicing variations are relevant for studies of development, gene regulation and neurodegenerative diseases.
    1. Structural Biology and Molecular Biophysics

    Modelling dynamics in protein crystal structures by ensemble refinement

    B Tom Burnley et al.
    A combination of molecular dynamics simulations and X-ray diffraction data has been used to construct more realistic models of proteins and to provide new insights into their interactions with other proteins and biomolecules.
    1. Developmental Biology

    Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron

    Nils O Lindström et al.
    The patterning of the nephron is driven by a gradient in the activity of β-catenin and further defined by a network of BMP, PTEN and NOTCH signalling.
    1. Cell Biology
    2. Immunology and Inflammation

    Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells

    Hiroshi Yamaguchi et al.
    Apoptotic cells release molecules to recruit macrophages, but do not cause inflammation because they also secrete AMP that functions as a ‘calm down’ signal.
    1. Biochemistry and Chemical Biology

    AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

    Sandra Galic et al.
    A single mutation in acetyl-CoA carboxylase blocking AMPK regulation inhibits food intake in mice in response to cold exposure or fasting causing them to lose weight.
    1. Developmental Biology

    BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity

    Richard H Row et al.
    Interplay between FGF-induced bHLH transcription factors and BMP-induced bHLH inhibitory id genes govern mesodermal cell fate choice along the mediolateral axis in both zebrafish and mouse.