2,548 results found
    1. Microbiology and Infectious Disease

    A single regulator NrtR controls bacterial NAD+ homeostasis via its acetylation

    Rongsui Gao et al.
    Functional definition of NrtR and the discovery of its acetylation represents a first paradigm for linking protein acetylation to bacterial central NAD+ metabolism.
    1. Neuroscience

    Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity

    Christopher W Mount et al.
    Oligodendrocyte precursor cells receive brain-wide, circuit-specific intracortical, coritcocortical and thalamocortical synaptic inputs.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

    Xiaocheng Zhao et al.
    The cAMP-dependent protein kinase A controls the switch from actively sprouting new blood vessel formation to vessel quiescence by reducing endothelial autophagy through phosphorylation-mediated destabilisation of ATG16L1.
    1. Cell Biology
    2. Genetics and Genomics

    The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response

    Karina Perlaza et al.
    A genetic screen in a unicellular photosynthetic organism uncovers the first essential signaling component in the chloroplast unfolded protein response that relays information from the chloroplast to the nuclear compartment.
    1. Neuroscience

    Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta

    Emelyne Teo et al.
    Metabolic defects following expression of Aβ1-42 in nematode neurons are partially caused by inactivation of alpha-ketoglutarate dehydrogenase and can be rescued by Metformin.
    1. Human Biology and Medicine
    2. Microbiology and Infectious Disease

    Rare missense variants in the human cytosolic antibody receptor preserve antiviral function

    Jingwei Zeng et al.
    Studying the impact of natural variation on a key immune gene highlights how focusing on a single wild-type sequence overlooks that rare variants cause the most disease.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The yellow gene influences Drosophila male mating success through sex comb melanization

    Jonathan H Massey et al.
    Melanization of a secondary sexual structure facilitates male mating success in Drosophila.
    1. Plant Biology

    Proximity labeling of protein complexes and cell-type-specific organellar proteomes in Arabidopsis enabled by TurboID

    Andrea Mair et al.
    Proximity-labeling using engineered biotin ligases TurboID and miniTurbo enables detection of cell-type-specific and low abundance protein complexes and subcellular proteomes in Arabidopsis and other plants.
    1. Chromosomes and Gene Expression

    Androgen-regulated transcription of ESRP2 drives alternative splicing patterns in prostate cancer

    Jennifer Munkley et al.
    The male steroid hormone testosterone regulates splicing patterns by controlling the expression of a key splicing regulator protein.

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