5,348 results found
    1. Neuroscience

    Using an achiasmic human visual system to quantify the relationship between the fMRI BOLD signal and neural response

    Pinglei Bao et al.
    The lower-level retinotopic visual cortex of humans born without the optic chiasm comprises two independent neuronal populations and forms a versatile model for quantifying the relationship between the fMRI BOLD signal and neural response.
    1. Microbiology and Infectious Disease

    Host genetic selection for cold tolerance shapes microbiome composition and modulates its response to temperature

    Fotini Kokou et al.
    Microbiome and transcriptomic profiling of genetically selected tropical fish with high and low tolerance to cold exposure revealed host control over microbiome composition and response to temperature changes.
    1. Biochemistry and Chemical Biology

    Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

    Gregory M Solis et al.
    Directly targeting the ribosome to attenuate translation partly mimics the integrated stress response, increasing lifespan and preserving protein folding capacity even in older individuals with dysfunctional stress response signaling.
    1. Chromosomes and Gene Expression

    A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans

    Wei Jiang et al.
    A gene regulatory program regulating thermal stress response and organismic death.
    1. Stem Cells and Regenerative Medicine

    Transient inflammatory response mediated by interleukin-1β is required for proper regeneration in zebrafish fin fold

    Tomoya Hasegawa et al.
    The Interleukin 1 beta signaling and tissue inflammation act as a double-edged sword: they are required for regeneration, but when in excess, they impair tissue regeneration and induce apoptosis.
    1. Neuroscience

    Response to short-term deprivation of the human adult visual cortex measured with 7T BOLD

    Paola Binda et al.
    Two hour deprivation of vision in one eye transiently boosts the representation of the deprived eye (suppressing the non-deprived eye) in adult human V1 and along the ventral pathway.
    1. Neuroscience

    What the success of brain imaging implies about the neural code

    Olivia Guest, Bradley C Love
    For brain imaging to be useful despite its limitations in measuring neural activity, the neural code must be smooth both in a traditional sense and functionally.
    1. Biochemistry and Chemical Biology

    AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

    Sandra Galic et al.
    A single mutation in acetyl-CoA carboxylase blocking AMPK regulation inhibits food intake in mice in response to cold exposure or fasting causing them to lose weight.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Definition of two agonist types at the mammalian cold-activated channel TRPM8

    Annelies Janssens et al.
    Two natural cooling agents activate the cold-activated channel TRPM8 via two opposite mechanisms, evoking distinct electrical responses in cold-sensitive neurons.

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