1,073 results found
    1. Cell Biology

    Two-signal requirement for growth-promoting function of Yap in hepatocytes

    Tian Su, Tanya Bondar ... Ruslan Medzhitov
    The Yap pathway requires two signals to promote organ growth: a cell intrinsic Hippo signal and a signal induced by injury or inflammation.
    1. Cancer Biology

    Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

    Caroline Contat, Pierre-Benoit Ancey ... Etienne Meylan
    In lung adenocarcinoma, deleting one glucose transporter, whether it is Glut1 or Glut3 is insufficient, whereas their dual deletion reduces tumor growth.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Extensive horizontal gene transfer in cheese-associated bacteria

    Kevin S Bonham, Benjamin E Wolfe, Rachel J Dutton
    The identification of horizontally transferred genes, and commonly transferred functions, can provide a window into the selective forces acting on species within an ecosystem.
    1. Ecology
    2. Evolutionary Biology

    Phylogenomic and mitogenomic data can accelerate inventorying of tropical beetles during the current biodiversity crisis

    Michal Motyka, Dominik Kusy ... Ladislav Bocak
    Integrated phylogenomics and mitochondrial DNA inventory of net-winged beetles across three continents suggest ~1000 undescribed species, biodiversity hot spots, and phylogeny-based classification that sets up the basis for further research.
    1. Microbiology and Infectious Disease

    Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis

    Allison Hillary Williams, Richard Wheeler ... Ivo Gomperts Boneca
    Lytic transglycosylase enhances the activity of its protein partner, and its catalytic domain can be targeted to disrupt cell-wall integrity, protein partner function, and bacterial survival (Neisseria meningitidis) in hosts.
    1. Neuroscience

    Fixation-pattern similarity analysis reveals adaptive changes in face-viewing strategies following aversive learning

    Lea Kampermann, Niklas Wilming ... Selim Onat
    A novel approach based on eye-movement patterns reveals adaptive changes during viewing of faces and fear generalization.
    1. Neuroscience

    Action sequence learning, habits, and automaticity in obsessive-compulsive disorder

    Paula Banca, Maria Herrojo Ruiz ... Trevor W Robbins
    Habit-based theories of obsessive-compulsive disorder are further elucidated by employing mobile phone motor sequence training, for which patients exhibited equivalent automatization, but enhanced value for the trained sequence, potentially ameliorating symptoms.
    1. Immunology and Inflammation

    T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks

    Karen E Tkach, Debashis Barik ... Grégoire Altan-Bonnet
    Experiment-driven quantitative model of IL-2 secretion demonstrates how T cells integrate their digital antigen responses into an analog-scaled output.
    1. Developmental Biology

    Neurogenic decisions require a cell cycle independent function of the CDC25B phosphatase

    Frédéric Bonnet, Angie Molina ... Eric Agius
    The cell cycle phosphatase CDC25B controls cell cycle progression and neurogenesis through independent pathways.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation

    André Mourão, Sophie Bonnal ... Michael Sattler
    Interactions with Sm proteins can provide a way in which regulatory factors can modulate alternative splice site choices.

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