21 results found
    1. Structural Biology and Molecular Biophysics

    Mechanism of Dimer Selectivity and Binding Cooperativity of BRAF Inhibitors

    Joseph Clayton, Aarion Romany ... Jana Shen
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Convincing
    1. Genetics and Genomics

    Identifying in vivo genetic dependencies of melanocyte and melanoma development

    Sarah Perlee, Yilun Ma ... Richard M White
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology

    Restraint of melanoma progression by cells in the local skin environment

    Yilun Ma, Mohita Tagore ... Richard M White
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Neuroscience

    A microglia clonal inflammatory disorder in Alzheimer’s Disease

    Rocio Vicario, Stamatina Fragkogianni ... Frederic Geissmann
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Cancer Biology

    FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation

    Chenxi Gao, Huaibin Ge ... Jing Hu
    Mice studies show that the 'just-right' balance optimal for BRAFV600E-induced cecal tumor formation can be achieved through FAK alteration.
    1. Cancer Biology
    2. Cell Biology

    EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation

    Ariel Pribluda, Anneleen Daemen ... Melissa R Junttila
    G9a regulates chromatin-bound b-catenin enabling cell-intrinsic control of WNT signaling-mediated cell fate decisions.
    1. Cell Biology
    2. Immunology and Inflammation

    Functional visualization of NK cell-mediated killing of metastatic single tumor cells

    Hiroshi Ichise, Shoko Tsukamoto ... Michiyuki Matsuda
    Live imaging of the duel of an NK cell versus a metastatic cancer cell on pulmonary epithelial cells reveals a novel survival tactics adopted by cancer cells.
    1. Cancer Biology
    2. Genetics and Genomics

    BRAFV600E induces reversible mitotic arrest in human melanocytes via microRNA-mediated suppression of AURKB

    Andrew S McNeal, Rachel L Belote ... Robert L Judson-Torres
    Oncogenic BRAF causes genome duplication and reversible growth arrest in human melanocytes that is conditional on microRNA expression and differentiation state.
    1. Cancer Biology
    2. Cell Biology

    RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

    Tomasz Radaszkiewicz, Michaela Nosková ... Vítězslav Bryja
    RNF43 interacts with receptor complexes of the Wnt/PCP signaling and its enzymatic activity results in the reduced cells sensitivity to WNT5A what translates in melanoma into decreased invasive properties and increased response to targeted therapies of this skin cancer.
    1. Cancer Biology
    2. Developmental Biology

    An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

    Rediet Zewdu, Elnaz Mirzaei Mehrabad ... Eric L Snyder
    Genetically engineered murine models reveal novel mechanisms of cell identity regulation in lung cancer and provide insights into the complex interplay between lineage specifiers and oncogenic signaling pathways in this disease.
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