365 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism

    Huasong Lu et al.
    A new potent and selective CDK9 inhibitor induces the expression of the proto-oncogene MYC via a mechanism that depends on the bromodomain protein BRD4.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma

    Gerard L Brien et al.
    BRD9 provides the first actionable therapeutic target in synovial sarcoma tumours that is both biochemically and functionally linked to the SS18-SSX fusion protein which drives disease development.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Acetylation of BMAL1 by TIP60 controls BRD4-P-TEFb recruitment to circadian promoters

    Nikolai Petkau et al.
    Acetylation of the circadian transcription factor BMAL1 by the acetyltransferase TIP60 is crucial for recruitment of the pause release factors to clock gene promoters and productive elongation of these genes.
    1. Biochemistry and Chemical Biology

    JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes

    Schuyler Lee et al.
    JMJD6 helps BRD4 to recruit CDK9 to RNA Polymerase II by disrupting 7SK snRNP complex.
    1. Chromosomes and Gene Expression

    Promoter-specific changes in initiation, elongation, and homeostasis of histone H3 acetylation during CBP/p300 inhibition

    Emily Hsu et al.
    CBP/p300 acetylation of histone H3 at promoters and enhancers stimulates transcriptional elongation through recruitment of the super-elongation complex and BRD4.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels

    Graeme Gossel et al.
    The maintenance of memory CD4 T cells in mice relies on a continual and strikingly high level of replenishment from naive precursors, and older memory T cells may resist the influx of newer ones.
    1. Cancer Biology

    NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency

    Joana G Marques et al.
    In fusion-positive rhabdomyosarcoma, CHD4 positively regulates super-enhancer-mediated gene expression by allowing a chromatin architecture at these cis-regulatory regions, which is permissive to the binding of the transcription factor PAX3-FOXO1.
    1. Developmental Biology

    tec-1 kinase negatively regulates regenerative neurogenesis in planarians

    Alexander Karge et al.
    RNAi screening in planarians finds that inhibition of the TEC-family protein tyrosine kinase tec-1 increases the regeneration of neurons through enhancement of cell survival.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A distinct transition from cell growth to physiological homeostasis in the tendon

    Mor Grinstein et al.
    Mitotic labeling defines a change in cell division kinetics from growth to homeostasis and identifies slowly cycling cells in the adult tendon.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages

    Maria A Sacta et al.
    A comprehensive analysis of the glucocorticoid-sensitive pro-inflammatory genes in macrophages reveals fundamental differences between the temporal events and components of transcriptional machinery that the glucocorticoid receptor targets to repress their transcription.

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