Alessia Soldano, Yeranddy A Alpizar ... Karel Talavera
Fruit flies can taste and avoid food contaminated with a bacterial toxin using the same channel protein that functions in humans as sensor of noxious chemical stimuli.
Deregulated cell fate specification pathways, including oncogenic Ras, cause activation of JNK-signaling at contact sites with wild type cells, which drives apoptosis and aberrant cell elimination in a contact-dependent manner.
Biochemical, molecular, and genetic analyses show that in Drosophila the epigenetic enzyme TET does not demethylate 6mA, which is scarce in the genome, but rather acts in a catalytic-independent manner.
Konrad Lang, Julian Milosavljevic ... Tobias Hermle
To maintain the filtration barrier, slit diaphragms are cleansed by rapid cycles of raft-mediated endocytosis, while dynamin-dependent endocytosis prevents lateral diffusion of slit diaphragm protein.
Tuned protein–protein interaction affinity optimizes the repressive function of the ETS family transcription factor Yan in order to contribute specificity and robustness to cell fate specification in the developing Drosophila eye.
Functional molecular analysis of cytokinesis in Caenorhabditis elegans four-cell embryos reveals cell-type-specific variation in the fundamental dependence on a robust f-actin cytoskeleton for successful cell division, mediated by both cell-intrinsic and -extrinsic pathways.
Johanna Lattner, Weihua Leng ... David Flores-Benitez
The polarity protein crumbs controls apical secretion and the architecture of the apical domain by modulating PI(4,5)P2 levels and the organization of apical Rab6-, Rab11-, and Rab30-dependent trafficking.
Timely regulation of growth cone dynamics, including filopodial and cytoskeletal rearrangements through phosphorylation signals from glial cells, shapes the photoreceptor axon targeting.
The Drosophila tracheal fate is stabilized by the combination of transcriptional programs to control tissue architecture and tissue-level input sensitive to tubular geometry, ensuring the robust mechanism of organ determination.
Sara E Vazquez, Elise MN Ferré ... Mark S Anderson
Humans with mutations in the AIRE gene exhibit common autoantibodies targeting ovarian and intestinal antigens, including intestinal dysfunction-associated antibodies to enteroendocrine transcription factor RFX6.
