2,885 results found
    1. Microbiology and Infectious Disease

    A lipoprotein/β-barrel complex monitors lipopolysaccharide integrity transducing information across the outer membrane

    Anna Konovalova et al.
    Mutations that block assembly of the interlocked RcsF/β barrel protein complex prevent detection of lipopolysaccharide stress and activation of Rcs signal transduction pathway.
    1. Cancer Biology
    2. Cell Biology

    The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells

    Shaheen Kabir et al.
    Targeting the CRL5 ubiquitin ligase complex in combination with CDK9 or MCL1 inhibition could combat innate and acquired resistance of cancer cells to MCL1-targeting therapeutics.
    1. Structural Biology and Molecular Biophysics

    Beam-induced motion correction for sub-megadalton cryo-EM particles

    Sjors HW Scheres
    Building on previous work (Bai et al., 2013), we describe an algorithm that allows cryo-EM structure determination to near-atomic resolution for protein complexes as small as 170 kDa.
    1. Cancer Biology
    2. Cell Biology

    Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

    Qian Liu et al.
    The pro-apoptotic BH3-protein Bim contains two distinct binding sites for anti-apoptotic proteins that together confer resistance of Bim/Bcl-2 and Bim/Bcl-XL complexes to BH3-mimetic drugs under development for use in humans.
    1. Cell Biology

    Disordered clusters of Bak dimers rupture mitochondria during apoptosis

    Rachel T Uren et al.
    Dimers of Bak assemble into clusters without using a distinct protein-protein interface, which may explain the apparent difficulties in obtaining high resolution structures of the pore complex and in targeting dimer-dimer interactions to regulate apoptosis.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases

    Cosimo Pinto et al.
    The nuclease of hDNA2 limits its processive DNA unwinding capacity; the helicase function becomes stimulatory when hDNA2 is in complex with BLM or WRN helicase to degrade dsDNA.
  1. Living Science: Owning your mistakes

    Eve Marder
    Most scientists admit to their errors but, as Eve Marder explains, the scientific community as a whole needs to rethink the way it recognizes achievement.
    1. Neuroscience

    Transcriptomics: Resting easy with a sleep regulator

    William J Giardino, Luis de Lecea
    Insight
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