726 results found
    1. Neuroscience

    Bayesian analysis of retinotopic maps

    Noah C Benson, Jonathan Winawer
    A novel Bayesian method of modeling retinotopic maps is more accurate than traditional voxel-wise methods and can be used to automatically derive high-quality maps.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis

    Laura Whitworth et al.
    In this ideal example of pharmacogenomics, individuals with a common variant in a gene encoding for an inflammatory lipid mediator benefit selectively from standard-of-care anti-inflammatory treatment used for tuberculous meningitis.
    1. Neuroscience

    Control of entropy in neural models of environmental state

    Timothy H Muller et al.
    Evidence for neuromodulatory control of flexibility in human neural models.
    1. Computational and Systems Biology

    Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

    Juliane Liepe et al.
    Experimental and computational analyses reveal how proteasomal hydrolysis is regulated and show that peptide transport is the rate-limiting step and the main differentiating factor between human standard- and immuno-proteasomes.
    1. Biochemistry and Chemical Biology

    Meta-Research: Task specialization across research careers

    Nicolas Robinson-Garcia et al.
    An analysis of author contribution statements in a large number of published papers reveals biases in the career trajectories of scientists.
    1. Neuroscience

    Active sensing in the categorization of visual patterns

    Scott Cheng-Hsin Yang et al.
    Humans use a near-optimal eye movement strategy to efficiently extract information about high-level visual categories.
    1. Evolutionary Biology
    2. Neuroscience

    Quantitative uniqueness of human brain evolution revealed through phylogenetic comparative analysis

    Ian F Miller et al.
    The exceptionally large size of the human brain is the result of accelerating evolution towards larger brains in hominins, but is not the product of neocortical expansion.
    1. Neuroscience

    Large-scale replication study reveals a limit on probabilistic prediction in language comprehension

    Mante S Nieuwland et al.
    Large-scale replication study with brain potentials challenges the view that people routinely predict the phonological form of a predictable word during language comprehension.
    1. Evolutionary Biology

    Neurocranial anatomy of an enigmatic Early Devonian fish sheds light on early osteichthyan evolution

    Alice M Clement et al.
    Stunning new scan data of an enigmatic fish from the Early Devonian of Australia, Ligulalepis, is identified as a stem osteichthyan, specifically, as the sister taxon to the 'psarolepids' plus crown osteichthyans.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

    Iain G Johnston et al.
    New modelling, statistics, and experiments show that cellular populations of mitochondrial DNA (mtDNA) evolve during development according to solvable stochastic dynamics involving binomial partitioning and random turnover, facilitating a predictive and quantitative theory of the mtDNA bottleneck.

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