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    1. Medicine
    2. Neuroscience

    High-intensity training enhances executive function in children in a randomized, placebo-controlled trial

    David Moreau, Ian J Kirk, Karen E Waldie
    Short bursts of high-intensity exercise elicit robust improvements in core cognitive abilities, especially in individuals whose genotype is associated with lower cognitive performance.
    1. Cancer Biology
    2. Cell Biology

    Actin networks modulate heterogeneous NF-κB dynamics in response to TNFα

    Francesca Butera, Julia E Sero ... Chris Bakal
    A live imaging and computational approach reveals feedback loops involving F-actin dynamics that regulate the NF-κB transcription factor RELA.
    1. Neuroscience

    Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making

    Karima Chakroun, David Mathar ... Jan Peters
    Dopamine attenuates exploration during decision-making via a reduction of neural tracking of uncertainty.
    1. Neuroscience

    Control of entropy in neural models of environmental state

    Timothy H Muller, Rogier B Mars ... Jill X O'Reilly
    Evidence for neuromodulatory control of flexibility in human neural models.
    1. Neuroscience

    Dopaminergic challenge dissociates learning from primary versus secondary sources of information

    Alicia J Rybicki, Sophie L Sowden ... Jennifer L Cook
    Haloperidol comparably affects learning from social and non-social sources when they are the primary source of information but does not affect learning from (social or non-social) secondary sources, providing evidence in support of domain-general neurochemical mechanisms underpinning social learning.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Genomic epidemiology of the first two waves of SARS-CoV-2 in Canada

    Angela McLaughlin, Vincent Montoya ... Jeffrey B Joy
    Canadian COVID-19 travel restrictions imposed in March 2020 greatly reduced SARS-CoV-2 importations, but were insufficient to prevent new sublineages of similar transmissibility from being introduced and replacing early sublineages.
    1. Cell Biology
    2. Evolutionary Biology

    Phylogenomic analysis supports the ancestral presence of LPS-outer membranes in the Firmicutes

    Luisa CS Antunes, Daniel Poppleton ... Simonetta Gribaldo
    Phylogenomics provides support for the Gram-positive type of bacterial cell envelope being a derived character that arose independently multiple times through loss of an ancestral outer membrane.
    1. Epidemiology and Global Health
    2. Medicine

    External validation of a mobile clinical decision support system for diarrhea etiology prediction in children: A multicenter study in Bangladesh and Mali

    Stephanie Chow Garbern, Eric J Nelson ... Daniel T Leung
    A smartphone app incorporating clinical prediction models using patient-specific and location-specific data sources in a modular approach could predict viral-only etiology of diarrhea in children under five in Bangladesh and Mali.
    1. Neuroscience

    Noisy neuronal populations effectively encode sound localization in the dorsal inferior colliculus of awake mice

    Juan Carlos Boffi, Brice Bathellier ... Robert Prevedel
    Bespoke volumetric calcium imaging, validated with neuropixels recordings, evidence a population code for sound azimuth at the dorsal cortex of the inferior colliculus, with a contribution of noise correlations.
    1. Microbiology and Infectious Disease
    2. Medicine

    A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

    Isaie J Reuling, Lisanne A van de Schans ... Teun Bousema
    Controlled human malaria infection model allows the study of gametocyte biology and dynamics providing novel insights and tools in malaria transmission and elimination efforts.