55 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates

    Maxim Y Balakirev et al.
    Wss1 is both a metalloprotease and SUMO ligase found in association with Cdc48 and Doa1 and accumulating in the vacuole upon DNA damage.
    1. Medicine

    Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer

    Fernanda I Staquicini et al.
    A peptide motif targeting tumor-infiltrating macrophage in triple-negative breast cancer delays tumor growth and favors an antitumor immune response.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration

    Guangyan Xiong et al.
    Genetic and biochemical analyses reveal that PERK is important for the survival of activated satellite stem cells during regeneration of injured skeletal muscle.
    1. Cell Biology

    Proinsulin misfolding is an early event in the progression to type 2 diabetes

    Anoop Arunagiri et al.
    Proinsulin misfolding, an established cause of diabetes in patients with INS gene mutations, is now observed in normal human pancreatic islets, and rodents with genetic predisposition to type 2 diabetes.
    1. Genetics and Genomics

    PRD-2 directly regulates casein kinase I and counteracts nonsense-mediated decay in the Neurospora circadian clock

    Christina M Kelliher et al.
    Casein kinase I, a pivotal kinase in the circadian clock encoded by ck-1a, is positively regulated by a novel RNA-binding protein that protects ck-1a transcripts from nonsense-mediated decay.
    1. Cell Biology
    2. Developmental Biology

    The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells

    Andrea Haag et al.
    The co-chaperone CHORDC1 is specifically required for epidermal growth factor receptor trafficking and signaling in Caenorhabditis elegans and in human cells.
    1. Cell Biology

    Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors

    Eszter Zavodszky, Ramanujan S Hegde
    ER-resident chaperones and cargo receptors make excursions to the cell surface and endocytic compartments when they accompany misfolded clients to lysosomes for degradation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

    Lars Plate et al.
    Small molecule proteostasis regulators that activate the unfolded protein response transcription factor ATF6 reduce the secretion of amyloid disease-associated proteins.
    1. Cancer Biology
    2. Cell Biology

    Secretion of protein disulphide isomerase AGR2 confers tumorigenic properties

    Delphine Fessart et al.
    Epithelial tumors secrete the ER-resident AGR2 in the extracellular matrix to function as a novel essential microenvironmental regulator of epithelial tissue architecture, which leads to tumorigenicity.
    1. Cell Biology
    2. Neuroscience

    The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains

    Vladimir Zhemkov et al.
    Signaling function of sigma 1 receptor is related to its ability to organize cholesterol-enriched microdomains in the endoplasmic reticulum membrane.

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