552 results found
    1. Structural Biology and Molecular Biophysics

    Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex

    Thomas E Sladewski et al.
    mRNA cargo orchestrates the activation of an in vitro reconstituted dynein-dynactin-Bicaudal D-Egalitarian complex for robust processive motion on microtubules.
    1. Cell Biology

    RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs

    Mark A McClintock et al.
    Reconstitution of dynein-based mRNA transport with purified components reveals a pivotal role of an RNA localisation signal in controlling the assembly and activity of the translocation machinery.
    1. Physics of Living Systems

    Origin and role of the cerebrospinal fluid bidirectional flow in the central canal

    Olivier Thouvenin et al.
    The combination of data and modelling shows the mechanisms underlying bidirectional flow of cerebrospinal fluid and its impact on long range transport in the CSF between brain and spinal cord.
    1. Developmental Biology
    2. Evolutionary Biology

    Evolution of limb development in cephalopod mollusks

    Oscar A Tarazona et al.
    Cuttlefish embryos reveal that cephalopod mollusks evolved specialized arms and tentacles by activating the same genetic circuits that control development of limbs in arthropods and vertebrates.
    1. Neuroscience

    Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms

    Zhipeng Qu et al.
    The zinc finger protein ZBTB20 is a morning and evening activity gating factor in mice.
    1. Neuroscience

    A role for descending auditory cortical projections in songbird vocal learning

    Yael Mandelblat-Cerf et al.
    Midbrain dopaminergic neurons and a cortex-like structure called the arcopallium form part of a circuit that enables young songbirds to compare their own song with a template stored in memory, and use any discrepancies to improve their performance.
    1. Developmental Biology

    Deficient spermiogenesis in mice lacking Rlim

    Feng Wang et al.
    Genetic analyses in mice identifies Rlim in the spermatogenic cell lineage as a regulator of cytoplasmic reduction during spermiogenesis.
    1. Neuroscience

    Natural ITD statistics predict human auditory spatial perception

    Rodrigo Pavão et al.
    Human brain has incorporated natural statistics of spatial cues to the neural code supporting perception of sound location.
    1. Computational and Systems Biology
    2. Developmental Biology

    A re-inducible gap gene cascade patterns the anterior–posterior axis of insects in a threshold-free fashion

    Alena Boos et al.
    The body axis of insects is divided into different fates using a self-regulatory and threshold-free mechanism.
    1. Cell Biology
    2. Developmental Biology

    Single-cell transcriptome analysis of avian neural crest migration reveals signatures of invasion and molecular transitions

    Jason A Morrison et al.
    Single cell transcriptome analysis of an embryonic collective migratory cell population provides new insights into the heterogeneity of transcriptional signatures within a neural crest cell migratory stream.

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