115 results found
    1. Cell Biology
    2. Developmental Biology

    bicoid mRNA localises to the Drosophila oocyte anterior by random Dynein-mediated transport and anchoring

    Vítor Trovisco et al.
    The localisation of bicoid mRNA depends on its microtubule-independent anchoring at the oocyte anterior.
    1. Developmental Biology

    Bicoid gradient formation and function in the Drosophila pre-syncytial blastoderm

    Zehra Ali-Murthy, Thomas B Kornberg
    The concentration gradient of Bicoid protein positions gene expression domains along the anterior/posterior axis of the Drosophila embryo during the cleavage, pre-syncytial blastoderm stages.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Concentration dependent chromatin states induced by the bicoid morphogen gradient

    Colleen E Hannon et al.
    Interplay between protein concentration, DNA binding and remodeling of the chromatin landscape in early embryogenesis determines how a single transcription factor can specify multiple distinct gene expression states.
    1. Developmental Biology

    In vivo proximity labeling identifies cardiomyocyte protein networks during zebrafish heart regeneration

    Mira I Pronobis et al.
    Proximity labeling-based proteomic strategies applied in zebrafish identify new insights into protein network changes in heart muscle cells during regeneration and implicate Rho A as a target of ErbB2 signaling during zebrafish heart regeneration.
    1. Developmental Biology

    Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo

    Anqi Huang et al.
    Cell fates endowed by higher Bicoid concentration require input for longer duration, demonstrating a temporally non-linear morphogen-mediated pattern formation.
    1. Genetics and Genomics

    Ancient mechanisms for the evolution of the bicoid homeodomain's function in fly development

    Qinwen Liu et al.
    Transgenic animals carrying reconstructed ancestral alleles reveal how two ancient mutations allowed a regulatory protein to evolve a controlling role in embryonic development in flies.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    AirID, a novel proximity biotinylation enzyme, for analysis of protein–protein interactions

    Kohki Kido et al.
    AirID provides highly interaction-dependent biotinylation for analysis of protein–protein interaction.
    1. Physics of Living Systems

    Quantitative dissection of transcription in development yields evidence for transcription-factor-driven chromatin accessibility

    Elizabeth Eck et al.
    Confronting different models of chromatin accessibility with temporally resolved transcription profiles favors a scenario where transcription factors actively, rather than passively, drive chromatin from the inaccessible to the accessible state.
    1. Stem Cells and Regenerative Medicine

    AIRE is a critical spindle-associated protein in embryonic stem cells

    Bin Gu et al.
    AIRE played novel roles in the mitosis process in embryonic stem cells and early embryo cells.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Dynamic multifactor hubs interact transiently with sites of active transcription in Drosophila embryos

    Mustafa Mir et al.
    The probability of transcription factors binding to their target sites is choreographed through the formation of dynamic multi-protein hubs that transiently interact with actively transcribing genes.

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