Behavioural evidence and computational analyses suggest that people tend to decline the pursuit of more rewarded goals because they, wrongly, expect them to require more effortful actions.

Proteomic and genetic analysis discovers a new cytoskeletal mechanism of presynaptic short-term plasticity common across neuronal cell types.

Cellular etiology of a human WASH complex mutation in mice reveals its specific roles in neuronal organelle trafficking and a surprising role in motor impairments.

The localisation of bicoid mRNA depends on its microtubule-independent anchoring at the oocyte anterior.

The concentration gradient of Bicoid protein positions gene expression domains along the anterior/posterior axis of the Drosophila embryo during the cleavage, pre-syncytial blastoderm stages.

AirID provides highly interaction-dependent biotinylation for analysis of protein–protein interaction.

Interplay between protein concentration, DNA binding and remodeling of the chromatin landscape in early embryogenesis determines how a single transcription factor can specify multiple distinct gene expression states.

Transgenic animals carrying reconstructed ancestral alleles reveal how two ancient mutations allowed a regulatory protein to evolve a controlling role in embryonic development in flies.

The hunchback transcription features are compatible with an equilibrium model with a short decay length Bicoid activity gradient as the sole source of positional information, while Zelda and Hunchback speed-up the process by different means.

Cell fates endowed by higher Bicoid concentration require input for longer duration, demonstrating a temporally non-linear morphogen-mediated pattern formation.