An experimentally constrained model shows that Escherichia coli faces fitness trade-offs in chemotaxis behaviors, and that adaptation of phenotypic diversity through altered gene regulation permits populations to resolve these trade-offs.

The TEN-domain of human telomerase mediates the direct interaction with TPP1 to drive telomerase recruitment to telomeres.

Structural analysis of the kinesin-13 MCAK bound to its C-terminal tail reveals the molecular basis for the conformation of kinesin-13 in solution and the mechanism that triggers long-range conformational changes upon microtubule binding.

TERT promoter mutations impair TERT silencing upon cellular differentiation and are sufficient to facilitate cellular immortalization without additional tumor selected changes, explaining why they are associated with a very specific tumor spectrum.

In yeast, the secondary pathway for recruiting telomerase to chromosome ends requires a component of telomeric transcriptionally silent chromatin.

An efficient response to DNA damage requires the assembly of actin filaments in the nucleus.

New labeling approaches for single-molecule fluorescence microscopy detect the monomeric catalytic subunit of human telomerase within cellular holoenzyme and minimal active recombinant enzyme.

The ubiquitin ligase ROQUIN cross-talks with cellular metabolic signals to generate protective T cell-dependent antibody responses.

Telomere length distributions can be used to infer important properties of stem cell proliferation.